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How the world got lost on
the road to an anti-aging pill
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August 12, 2017: by Bill Sardi
Oligarch: a very rich business leader with a great deal of political influence.
Main points:
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August 3, 2017: by Bill Sardi
For decades now researchers have been saying what they are learning from young children with a gene mutation that results in premature aging and a shortened life span could have application for the rest of humanity. Don’t believe it.
News headlines declare a breakthrough in progeria, the name given to this premature aging syndrome. Researchers claim by maintaining the length of end caps of chromosomes called telomeres they can push back against this genetic disorder.
The prevalence of progeria is 1 in 4-8 million births. Progeroid children are prematurely old. There are only 145 of them in the world (~16 in the USA). They develop cataracts, wrinkled skin, become bald and die of a heart attack or stroke in their early teens. Progeria emanates from a mutation in the Lamin-A gene.
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July 29, 2017: by Bill Sardi
Since inflammation is a component of virtually all diseases the molecular mechanisms leading to the anti-inflammatory effects of resveratrol deserve more attention, say researchers.
Among the myriad biological actions of resveratrol, a chief property is its anti-inflammatory action. [Journal Medicinal Food April 2017] While many of the mechanisms behind its anti-inflammatory action have been described, this does not mean that present explanations are totally inclusive. In fact, it appears resveratrol works independently of the Sirtuin1 survival gene, which is not involved in its anti-inflammatory action.
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July 20, 2017: by Bill Sardi
If 80-year old John McCain undergoes the same care Joseph “Beau” Biden and Ted Kennedy underwent for their brain tumors, he is a walking dead man.
This aggressive form of brain cancer (glioblastoma) has a dire prognosis. There is no cure and treatment is only directed at relieving pain and suffering. With optimal treatment GB patients have a median survival of less than 1 year (3-year survival is only 2%).
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July 18, 2017: by Bill Sardi
This report is going to introduce a new word to your vocabulary, neoteny. But before that, allow me a few paragraphs to properly introduce this intriguing subject.
In the modern world where growing old age is now becoming optional and anti-aging pills are on the cusp of becoming reality, the question arises: who wants to live longer just to grow old?
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June 30, 2017: by Bill Sardi
A debate broke out recently between biologists who study human aging. One side of the argument claims the number of people reaching a theoretical maximum lifespan (~115 years) has not increased. On the other side of the argument biologists argue there is no scientific support for the claim the maximum lifespan is fixed ~115 years. [Nature June 29, 2017]
Between 1969 and 1995 there was an uninterrupted increase in maximum reported age at death. But that advance in longevity appears to have reached a plateau.
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May 21, 2017: by Bill Sardi
Just take a gander at all the Hollywood celebrities who have lived into their tenth decade of life. Actor Kirk Douglas (100); Actress Carol Channing (96); Betty White (95); Entertainer Carl Reiner (95); Actress Doris Day (94); Angela Lansbury (91); Dick Van Dyke (91); Jerry Lewis (91); Mel Brooks (91); singer Tony Bennett (90). You’re likely to live that long too! [ListAl.com]
The collective efforts of the younger will be to support the older. Short of adoption of an anti-aging pill that will prolong the HEALTHSPAN along with the lifespan of Americans, that will be how we measure tomorrow’s economy,
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April 7, 2017: by Bill Sardi
The race to prove the first anti-aging pill just got a bit more interesting if not closer to reality. The latest anti-aging pill is POOP. Yep, you heard it right. Excrement.
The bacteria from the feces of young killfish was transferred to older killfish with a startling prolongation of life — +41% longer, enough to nearly equal the long heralded doubling of the healthspan and lifespan of rodents achieved by a calorie restricted diet in the animal lab.
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March 28, 2017: by Bill Sardi
Want to achieve superlongevity as the Biblical patriarchs were reported to have achieved? Lengthen your telomeres (end caps on chromosomes) say some scientists.
Want to live an unlimited lifespan? Switch on a family of survival genes known as Sirtuins. Resveratrol pills do this.
Deprive yourself of food. Eat only one modest meal a day and go hungry most of the time. This same dietary practice doubled the healthspan and lifespan of laboratory animals and likely does the same for humans.
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March 24, 2017: by Bill Sardi
Time and again science reporters leave their reading audiences wanting as they break a news story about yet another high technology anti-aging pill they say will be years in the making but fail to point to readily available off-the-shelf remedies that do the same thing.
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