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How the world got lost on
the road to an anti-aging pill
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May 29, 2012: by Bill Sardi
Yes, what is obvious has been confirmed. Despite unfounded claims that all of the research studies showing resveratrol protects heart muscle tissue during a heart attack, even Wikipedia spreads misinformation that that fact is in question due to bogus allegations of scientific fraud against a leading resveratrol scientist. Canadian researchers unequivocally show that resveratrol protects the heart under conditions of biological stress induced by instillation of hydrogen peroxide by maintaining antioxidant enzymes (catalase, superoxide dismutase). Once damaged (scarred), heart muscle cells (cardiomyocytes) are not rapidly repaired. So it is critical to protect these cells. Resveratrol does something that no existing cardiac drug an do — protect the heart prior to a heart attack (this is called cardioprotection). It has been called the most ideal form of heart protection. Based upon animal lab studies, cardioprotection has been demonstrated to have the potential to turn otherwise mortal heart attacks into non-mortal events, which is more than aspirin or statin drugs can do. — Bill Sardi, ResveratrolNews.com
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May 16, 2012: by Bill Sardi
The fact is, such a pill already exists.
Click on the underlined links above to learn more.
–Bill Sardi, ResveratrolNews.com
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May 9, 2012: by ResveratrolNews
From: The Association for Research in Vision & Ophthalmology (ARVO) annual meeting, Fort Lauderdale, Fla.,
Ft. Lauderdale, FL (May 6, 2012) – There may be new found hope for patients whose vision is threatened when medicine injected directly into the eyes fails to cause abnormal blood vessels to recede. While injectable drugs called angiogenesis (an-gee-oh-jen-esis) inhibitors are considered a modern miracle and have become the standard of care for patients with the fast-progressive form of macular degeneration, they are not foolproof. For the first time researchers report that an oral nutriceutical, used on a last-resort clinical basis, rapidly restores vision to otherwise hopeless patients who face permanent loss.
Stuart Richer OD, PhD, Director, Ocular Preventative Medicine-Eye Clinic, James A. Lovell Federal Health Care Center, North Chicago, Illinois, says all other therapies were exhausted before employing the oral nutriceutical under compassionate-use protocols on a case-by-case basis. Usually most patients respond to medicine injected directly into the eyes, he says, but only about one in three patients recover driving vision and one in six patients go on to experience permanent vision loss and others may refuse needle injections directly into the eyes, making them candidates for this rescue medicine.
Three successfully treated cases were presented at the annual Association for Research in Vision & Ophthalmology meeting in Ft. Lauderdale, Florida.
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May 2, 2012: by Bill Sardi
http://www.nrcresearchpress.com/doi/pdf/10.1139/y2012-065
Dr. Thomas Netticadan
Canadian Centre for Agri-food Research
in Health and Medicine,
Winnipeg, Manitoba
Thank you for your comments published at Canadian Journal Physiology & Pharmacology regarding resveratrol research. ( http://www.nrcresearchpress.com/doi/pdf/10.1139/y2012-065 )
Let it be said that:
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April 21, 2012: by ResveratrolNews
Abridged summary: researchers have found that even very low dose intermittent exposure (twice in a 5-day period) to hydrogen peroxide, which is generated by exposure to unfiltered sunlight, induces aging of cells in the outer layer of the skin (epidermis) but that the red wine molecule resveratrol completely blocks senescence of these cells which may be chronically exposed to solar ultraviolet radiation.
Researchers in the experiment presented below show that hydrogen peroxide (H2O2-)induced premature senescence in primary human keratinocytes (cells found in the outer layer of the skin/epidermis) can be prevented by AMPK activation. (AMPK is a master metabolic activating enzyme.)
Cells that are senescent are no longer capable of dividing and skin renewal. Thus, researchers found that: (1) a low dose of hydrogen peroxide (H2O2 50 µM) activates two primary genes (p53 and secondarily p21)in these cells and subsequently increased SA-Galactosidase (SA-Ga1) activity, a marker of cellular senescence, and that (2) prior activation of AMPK by resveratrol prevented these H2O2-induced changes
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April 17, 2012: by Bill Sardi
According to a recent survey, 1 in 10 drugs were prescribed for off-label (unproven) uses, most which were not substantiated by existing science. (Archives Internal Medicine April 16, 2012). Physicians frequently respond to patient inquiries about dietary supplements by saying they are “unproven.” However, that doesn’t seem to bother physicians if it is a drug.
Furthermore, there is no drug that cures cancer (chemotherapy drugs only need to temporarily shrink a tumor by 50% before drug/tumor resistance sets in to gain FDA approval).
There is no single drug (diuretics, beta blockers, ACE inhibitors, calcium blockers) that adequately controls high blood pressure, and then none address the most common cause of hypertension (inability of blood vessels to dilate upon mental or physical exertion).
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April 12, 2012: by Bill Sardi
Noted herbal researcher Bahrat Aggarwal PhD, of the University of Texas MD Anderson Cancer Center in Houston is the second major herbal researcher to be accused of scientific fraud this year. Word that 65 of his published papers were under scientific review began to be leaked first on the internet before news reports confirmed an investigation is underway.
Like Dipak Das, PhD, the University of Connecticut researcher who was charged with over a hundred counts of scientific deceit in January of this year, both researchers stand accused of altering graphic images in their published papers. And in both instances, there is unequivocal evidence of altered images in these published papers. However, interpretation of whether these altered images represent honest mistakes or intentional trickery is a bit more difficult.
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April 3, 2012: by Bill Sardi
The scourge of making a cheap sugar from corn is the prevalent plague of diabesity that has changed American waist lines and forced many into life-long insulin injections. An antidote to high fructose corn syrup (HFCS) would be ideal if Americans can’t back away from their desire for sweets. Sugars do create cravings for more sweet stuff as sugar-craving yeast overgrow in the digestive tract. About 50% of sugar intake in western society is derived from HFCS sugar in soft drinks. Certainly Americans have become hooked on this cheap sugar and are paying the price not only with poor health but rising health care costs. And to think HFCS was developed by none other than the US Department of Agriculture. So researchers in Eastern Europe put resveratrol, known as a red wine molecule, to the test to see if it would counter the adverse effects of HFCS. Whereas HFCS causes triglycerides and very-low density lipoproteins (cholesterol) to rise as well as blood pressure and insulin levels in laboratory rats, resveratrol supplementation “efficiently restored HFCS-induced deteriorations” said researchers. Here is the comparative data:
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April 2, 2012: by Bill Sardi
After 33 months, grey mouse lemurs who were given a 30%-lower calorie diet experienced an 81% reduction in insulin resistance (inability of cells to utilize insulin) while another group of animals given mega-dose resveratrol (200 milligrams per kilogram of body weight, or 14,000 mg human equivalent dose) experienced a 53% reduction in insulin resistance. Neither calorie restriction nor resveratrol produced any significant beneficial effects at 21 months suggesting beneficial effects for humans may take time to be realized. The study was published in a recent issue of the PLos One journal.
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: by Bill Sardi
All balding males pay attention. Put two-and-two together here. Resveratrol is potentially a remedy for baldness. Researchers have found that balding scalp areas exhibit high levels of an inflammatory agent called prostaglandin D2 (PDG2). See the first reference posted below. PGD2 inhibitors would serve to preserve hair growth. Why wait for expensive medicines? Resveratrol strong suppresses PGD2 at low concentration, as evidenced in the second reference provided below. Maybe resveratrol pills should be sold with a comb. — Copyright 2012 Bill Sardi, ResveratrolNews.com
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