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How the world got lost on
the road to an anti-aging pill
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April 1, 2012: by Bill Sardi
In the past decade or so red-wine resveratrol has been the most intensively studied anti-aging molecule. Resveratrol’s calling is that of a molecular mimic of a calorie-restricted diet that has been found to double the lifespan of all life forms tested.
Despite all the research, the confirmation of the first anti-aging pill has been elusive if for no other reason than the impracticality of conducting a long-term study to validate such an idea. The only conclusive evidence would be a long-term (many decades long) study. Many thousands of people would have to be followed for 8-10 decades to produce convincing data.
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March 29, 2012: by Bill Sardi
Yep, despite all of the evidence that resveratrol produces far greater and safer biological action at relatively low doses, biologists administered the human equivalent of 8000 milligrams of resveratrol to laboratory mice and found this “miracle molecule” to be ineffective at prolonging the life of these animals.
Why is this so? Are these researchers intentionally attempting to throw resveratrol under the bus? This question gets asked because all of these researchers are certainly aware of the hormesis effect, that a low-dose biological stressor activates key defenses in the body whereas a high-dose toxin is potentially lethal. Some of these researchers have even written about hormesis and resveratrol.
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March 23, 2012: by Bill Sardi
Worldwide headlines herald a test that may make it possible for cardiologists to predict an impending heart attack. The test may be particularly beneficial for people who have silent (non-painful) heart attacks or heart attacks that cannot be detected by conventional methods.
Compared to healthy adults, four times as many loose cells that slough off the inner lining of arteries, called endothelial cells, were found among heart attack patients who arrived at a hospital emergency room complaining of chest pain. A quicker and more efficient test is now being developed to count circulating endothelial cells in a blood sample.
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March 22, 2012: by Bill Sardi
With billions of dollars being spent on cancer research there is yet be declared any clearly proven measure to prevent cancer. Nor is there any proven cure once cancer is diagnosed. So the news headline that resveratrol (a red wine molecule) and genistein (a molecule found in soybeans) may be unique and promising anti-cancer agents is striking given all the money that is spent to develop synthetic anti-cancer drugs.
The problem is — I am not talking about the most recent scientific report about these molecules which says resveratrol and genistein are cancer-killing molecules that do not harm the DNA in healthy cells and are far less problematic than existing chemotherapy drugs, but about a similar report issued over a decade ago!
Nearly a decade ago pioneer researcher John M Pezzuto said, in regard to resveratrol, that “preclinical toxicity studies are underway that should be followed by human clinical trials. Imagine, resveratrol blocks cancer at all three stages of development – initiation, growth and spread (metastasis) – something no anti-cancer drug can do, yet there are few if any human clinical trials.
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March 8, 2012: by Bill Sardi
(March 8, 2012)- Millions of Americans are paying with their lives and their eyesight for the US Food & Drug Administration’s denial that nutriceuticals prevent, treat or cure disease says Bill Sardi, dietary supplement industry executive and health writer, speaking at the annual Nutracon meeting in Anaheim, CA this week.
“Nutriceuticals, a more sophisticated name for dietary supplements, do in fact prevent, treat and cure essential nutrient deficiency diseases such as vitamin D for rickets, vitamin C for scurvy, vitamin B1 for beri beri, as well as many chronic diseases, yet the FDA bans (censors) statements of fact, keeping the public in the dark over the obvious health benefits and cost effectiveness of nutriceuticals,” says Sardi.
“The US FDA maintains a narrow pharmaceutical model for chronic diseases, which are basically treated as drug deficiencies. The FDA maintains dietary supplements must become expensive drugs before statements can be made they cure or treat disease, which is absurd,” says Sardi.
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February 16, 2012: by Bill Sardi
Exclusive at www.resveratrolnews.com
Jennifer Aniston, arguably judged the most attractive female on the planet at the moment, has risen to this “most admirable” spot at age 43. Menshealth.com goes a step further, anointing Aniston as the hottest woman of all time.
According to an article in the Sydney Morning Herald, Aniston says she maintains her shape and beauty by daily exercise, pumping small hand weights in hotel rooms, and taking dietary supplements such as fish oil and resveratrol (rez-vair-ah-troll), the red wine molecule. No wonder she gets admired by a male health mag, her pill regimen beats that of most celebs who have been known to pop stimulants of all kinds. No, Aniston is not likely to enter rehab anytime soon to go through withdrawal from resveratrol pills. Is the fairer sex missing some beauty secret here? Maybe.
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February 10, 2012: by Bill Sardi
Over eight years after a Harvard University researcher mistakenly identified the primary gene target of resveratrol (rez-vair-ah-troll) as a survival gene (Sirtuin1) that is also variably activated by calorie restricted diets, National Institutes of Health (NIH) researchers say they have now identified an enzyme (phosphodiesterase4 or PDE4) as the first gene target of resveratrol. Specifically, this enzyme is inhibited by resveratrol, known as a red wine molecule. All of the antioxidant molecules in red wine are enzyme inhibitors.
The Sirtuin1 gene is not totally out of the picture, it is activated indirectly in the gene pathway along with other important metabolic gene targets such as NAD, PGC1a and AMPK. The study, which was conducted in mice, needs to be replicated in humans.
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February 5, 2012: by Bill Sardi
Unless you are a died-in-the-wool resveratrol pill user, you are likely having doubts over whether you should continue taking these so-called red wine pills now that the science published by a leading researcher in the field has been called into question (more about that below). Strangely enough, the science behind resveratrol’s miraculous ability to protect the human heart is very well founded, but when did solid science ever influence consumers anyway?
The record shows consumers of resveratrol pills are more likely to fall for a phony sales pitch rather than phony science. Except for a brief period in 2009 when online spammers falsely claimed their products were endorsed by Oprah Winfrey, pandered resveratrol pills as a cure-all for whatever ails mankind, made free bottle offers that came with fine print and unwanted monthly $85 credit card billings for more resveratrol pills and sold millions of bottles of these pills, consumers of dietary supplements have not widely adopted resveratrol pills into their daily pill regimens and appear to be paying a steep price for it with their lives.
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February 4, 2012: by admin
It’s Not Sirtuin1, it’s cAMP-dependent phosphodiesterases
While researchers have argued over whether Sirtuin1 is the direct or indirectly-activated gene responsible for its molecular mimicry of calorie restriction, researchers now claim resveratrol works directly by inhibiting enzymes called cAMP-dependent phosphodiesterases which then triggers a cascade of events that includes Sirtuin1. You also see the name of a pharmaceutical company in Japan participating here. (see attached paper)
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January 30, 2012: by admin
In recent days allegations of scientific fraud by a leading researcher who has conducted experiments using resveratrol, a red wine molecule, have been aired. Negative news report have cast a pall over the idea of drinking red wine or red wine pills as an elixir for what ails the heart. Was the science behind red wine pills all made up, as one popular radio commentator recently said? Preventive cardiologist Nate E. Lebowitz, M.D., FACC, with the Advanced Cardiology Institute in Ft. Lee, New Jersey, answers questions on this topic:
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