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How the world got lost on
the road to an anti-aging pill
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October 2, 2011: by ResveratrolNews
So many times this author has lamented at how brainwashed Americans have become. Shown a picture of a 100-year old man blowing out the candles on his birthday cake, almost every person responds by saying “I never want to live that long.”
Strange isn’t it, the promise of super longevity, what Spanish explorer Juan Ponce de Leon long sought after, to conquer aging, the scourge of humanity, is no longer on the minds of most Americans.
An anti-aging pill didn’t top the list of desired inventions in an MIT survey conducted years ago – beat out by biodegradable plastic, a driverless car and an fully automated home, of all things.
While we may distance ourselves from any idea of lining up to die like people did in the movie Soylent Green, where people who had expired were processed into food in an overpopulated world where food shortages were rampant. But most Americans say they favor quality over quantity of life, as if these two never coexist.
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September 28, 2011: by Bill Sardi
All roads to adult wellness and longevity lead to resveratrol, but the public isn’t buying it. An estimated 345 producers of dietary supplements have all raced to enter their version of resveratrol pills into the marketplace, but not much more than 100,000 American take these red wine pills. It is inexplicable why resveratrol continues to astound in the research laboratory but physicians are loathe to recommend it and consumers reticent to take this pill that may be the pill that ends all other pills.
The broad biological scope of the red wine molecule resveratrol is becoming legendary. Dr. Dipak Das at the University of Connecticut has documented the large number of genes that resveratrol controls. Resveratrol is beneficial for brain, heart, liver, blood circulation, immunity, cholesterol, blood clotting, etc, etc. It is difficult to address the breadth of resveratrol’s biological action without writing an encyclopedia.
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September 26, 2011: by Bill Sardi
While online scientific reports published in the last 30 days, registered at Pubmed.gov– the National Library of Medicine’s access page to thousands of scientific journals, were saying the red wine molecule resveratrol (rez-vair-ah-troll) protects heart muscle cells prior to a heart attack, blocks lesions that occur in the back of the eyes in an animal model of diabetes, has the potential to ward off age-related brain disorders and has strong anti-tumor activity, a number of major news media outlets were airing headlines stories which said something to the contrary:
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September 22, 2011: by Bill Sardi
Nothing new here, we’ve discussed this a couple of times in prior reports, that the road to longevity is not dependent upon a single gene, nor solely upon the Sirtuin1 survival gene, and it doesn’t require 1000 bottles of red wine to produce the same positive biological effects seen in the animal lab. But red-wine resveratrol pills are back in the headlines again today for yet another round of scientific scrutiny
“It turns out, the researchers who brought us to the longevity party may have had the wrong gene target in mind and maybe the elixir for perpetual youth is more of a low-octane mixed drink closer to that found in red wine rather than plain resveratrol juice, but we need to recognize there was no scientific or public interest in longevity pills till 2001 when MIT and Harvard researchers first identified a key gene that is activated when living organisms are placed on a limit calorie diet,” says Bill Sardi, spokesperson for Longevinex®, a leading maker of resveratrol pills.
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August 30, 2011: by Bill Sardi
They die, one every minute.
A sudden blockage of blood circulation in one or more coronary arteries results in damage to heart muscle that many cannot survive.
They represent as many as 1 in every 6 deaths in the U.S.
They are American adults whose lives should have been saved but weren’t.
There are 16 million of them at high risk who have been diagnosed with coronary artery disease.
The baby aspirin tablets, the statin cholesterol-lowering drugs, the streptokinase clot busters and inserted catheter balloons that break up clots in coronary arteries aren’t saving as many lives as advertised. Baby aspirin doesn’t sufficiently inhibit clots in heart arteries and a standard aspirin tablet induces bleeding gastric ulcers that can be mortal in themselves.
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August 23, 2011: by ResveratrolNews
So why is resveratrol averting mortal heart attacks in the animal lab, in preliminary studies restoring vision to humans who are battling an otherwise hopeless eye disease, and is considered to be the most promising anti-cancer molecule on the planet — and therefore addresses the three most feared health problems of humanity — yet relatively few Americans have adopted res-pills into their daily health regimens?
These questions and more are answered by Bill Sardi in his most recent e-book THE CASE FOR RESVERATROL: Why Aren’t More Americans Taking Resveratrol Pills?
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August 19, 2011: by Bill Sardi
Sirtris’ re-emergence with its Sirtuin1-gene activating SRT1720 drug gains the attention of the pharma world and health seekers. Most striking was that high-fat-fed mice did not gain weight, something that was only demonstrated in rodents with a supra-high dose of resveratrol (21,000 mg human equivalent dose). However, to produce this effect and overcome fatty liver SRT1720 had to be given in a 100 mg/kilogram dose, equivalent in human terms to 7000 mg for a 160-lb human. I’m not sure healthy humans are going to want to take seven 1000 mg pills a day, and at what cost? Lower dose (2100 mg human equivalent dose) SRT1720 produced a much more tempered effect and a modest improvement in life span. So maybe humans who are killing themselves by eating high-fat diets would benefit from this drug, but maybe not healthy people. Recognize the lab mice in this experiment were fed a 60% fat-calorie diet whereas humans generally consume 20-25% fat calorie diets. As a scientific achievement, SRT1720 is notable, but it doesn’t yet translate into a practical or affordable medicine for humans. The claim was these so-called new chemical entities under development by Sirtris were 1000-fold more powerful than resveratrol, but the dose required to produce a 44% increase in life span (about what a limited calorie diet achieves) is still quite high. And while there were no signficant side effects, this was true for mega-dose resveratrol in animal models of treatment for multiple myeloma (bone marrow cancer), but when 5000 mg of resveratrol was given to humans with this type of cancer it rapidly induced kidney failure. Bottom line, SRT1720 is a scientific achievement that is a long way from becoming an anti-aging drug. – Bill Sardi, ResveratrolNews.com
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August 18, 2011: by Bill Sardi
The announcement today, published in The New York Times, that a synthetic drug, SRT1720, produced by Sirtris Pharmaceuticals, mimics resveratrol and overcomes fatty liver which results in a 44% increase in the life span of laboratory animals, is the re-emergence of this company’s visibility since its failed (but half-hearted) venture to market a resveratrol pill. GlaxoSmithKline, the parent to Sirtris, abandoned further research and development for its SRT501 resveratrol (rez-vair-ah-trol) drug when mega-doses induced kidney failure in a human trial among bone marrow cancer patients.
The quest to develop these small-molecule drugs began in 2003 when Harvard researchers linked a resveratrol, a red wine molecule, with a key gene — Sirtuin1 – thought to be activated in calorie restricted animals that results in prolongation of life span.
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July 4, 2011: by Bill Sardi
A scientific review reveals resveratrol (rez-vair-aw-troll), known as a red wine molecule, simultaneously removes fatty plaques from arteries and the brain via its ability to control copper.
In 2009 researchers demonstrated resveratrol’s ability to inhibit cholesterol plaque accumulation (atherosclerosis) in arteries by its ability to promote efflux (exit) of cholesterol from the liver rather than interfere with cholesterol production in the liver as statin drugs do. Via its ability to bind with copper, resveratrol negates unbound copper’s susceptibility to harden cholesterol and form arterial plaque.
In a lab dish, resveratrol’s ability to reduce oxidation (hardening) of cholesterol (LDL- low-density lipoproteins) “was found to be mainly due to its capacity to chelate copper.”
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June 30, 2011: by Bill Sardi
* SOD = superoxide dismutase
Genes they be — a Sirtuin family of seven “silent information regulators” that are guardians of the cell. Sirtuins have been linked with prolonged lifespan in various life forms, starting with yeast cells, fruit flies and roundworms.1
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