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How the world got lost on
the road to an anti-aging pill
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December 15, 2010: by Bill Sardi
Apple polyphenols extend life in roundworms similar to resveratrol, which points to small molecules that control iron and copper as exerting these life-prolonging effects. Resveratrol is solely a copper chelator but also controls iron indirectly. This report further substantiates the over-mineralization theory of aging.
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December 12, 2010: by Bill Sardi
Since 2003 when a Harvard researcher extolled the SIRTUIN1 gene as the holy grail of anti-aging, this gene has only diminished in its stature. Out of a library of about 25,000 human genes, about 832 are believed to be involved in producing longevity as evidence in calorie-restricted animals whose lifespan is approximately doubled. Longevity involves many genes, not a sole gene target.
Resveratrol, the red wine molecule, which has been claimed to stimulate the SIRTUIN1 gene to produce proteins, has been shown to protect brain cells in models of Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (Lou Gehrig’s disease).
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December 1, 2010: by ResveratrolNews
Human and Experimental Toxicology, 29(12) 1016–1017
Dipak K Das
Cardiovascular Research Center, University of Connecticut, Farmington, CT, USA
Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol.
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November 29, 2010: by Bill Sardi
Harvard scientists say they have successfully restored youthfulness to old mice by re-activating telomerase in telomerase-deficient mice (telomerase is the enzyme that repairs the end-caps of chromosomes known as telomeres). In just one month of telomerase therapy “aged, mice, equivalent to 80-year-old humans, and were about to pass away,” were restored to “the physiological equivalent of young adults.” The report emanates from Nature Magazine today.
As spectacular as this laboratory study is, the question remains whether an experiment where mice are genetically bred to age prematurely applies to human aging. At the genetic level, human aging appears to largely involve epigenetics (switching of the TERT gene), not gene mutation as in the case of these mutated laboratory mice.
However, there are remarkable findings in this report that go overlooked. The youthful changes in these mice (their shrinking brains and sperm-producing glands got bigger, and their sense of smell returned) correlated with the lengthening of telomeres. These changes were obviously produced via epigenetic changes that countered inbred (mutational) factors. That should have been the real headline. Man’s biological destiny may not be permanently locked in his genes.
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November 28, 2010: by Bill Sardi
Eugene D. Weinberg PhD is emeritus professor in biology at Indiana University and long-time authority on iron overload. His recent landmark paper, entitled The Hazards Of Iron Loading, published in the November issue of Metallomics (Volume 2, pages 732–740, 2010), provides authoritative evidence for the predominant role of iron in human aging.
Consider some of the striking facts that Dr. Weinberg presents in his report:
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November 20, 2010: by Bill Sardi
Comment: for all resveratrol-followers out there, researchers find that activation of the 5-lipoxygenase gene is key to the formation of beta amyloid plaque formation in the brain, thought to be involved in Alzheimer’s disease. While there is no available drug specifically designed to inhibit 5-lipoxygenase, resveratrol, a natural enzyme inhibitor and metal (copper) chelator, inhibits 5-lipoxygenase.
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November 19, 2010: by Bill Sardi
Mice lacking the Sirtuin3 gene develop hearing loss via the production of free radicals that damage the power plants (mitochondria) within living cells, said researchers in a newly published report in the journal CELL today.
Researchers report the Sirtuin3 gene is essential in producing the health and longevity effects of a limited calorie diet. The Sirtuin3 gene increases antioxidant activity (glutathione, pronounced glu-tah-thigh-on) in mitochondrial compartments within living cells, thus preventing age-related hearing loss. The mitochondria are small organelles that a found within living cells that produce cellular energy in the form of adenosine triphosphate (ATP).
So far Sirtuin3 has taken a back seat to Sirtuin1 in longevity research, but possibly the entire family of Sirtuin “survival genes” will eventually be linked to longevity mechanisms. The entire research report can be viewed here.
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November 18, 2010: by Bill Sardi
In a feature article appearing in Australian Life Scientist entitled “The Science of Longevity: Resveratrol and Beyond,” Harvard biologist and longevity researcher David Sinclair PhD, whose research studies involving the activation of the Sirtuin1 longevity gene by the red wine molecule resveratrol have been recently called into question, now says he will soon reveal a “protein partner that is part of the mechanism,” a protein which explains why resveratrol works in some laboratory studies and not in others.
The article in Life Scientist says Sinclair is keeping the details of this protein partner “close to his chest,” he will be revealing it at the Australian Health & Medical Research Congress now underway. Sinclair says “We’ve found the missing piece to the puzzle that will make sense of all the data they’re arguing about, a piece people haven’t realized was missing…. People didn’t know you need to add it for it to be physiologically relevant.”
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November 16, 2010: by Bill Sardi
Las Vegas, NV (Nov. 16, 2010) – University-based researchers report today in the Canadian Journal of Physiology & Pharmacology that a resveratrol-based nutriceutical (Longevinex®) induces longevity effects at low dose in laboratory animals.
Also, as expected, Longevinex® (pronounced long-jev-in-ex) limited damage to the heart after an intentionally-induced heart attack. Longevinex® reduced the size of the experimentally-induced heart attack from 37% to 23% of heart tissue, sufficient for the heart to survive this adverse event. There was markedly less scar tissue (fibrosis) following the heart attack. If the results of this animal study are applicable to humans, many thousands of heart-attack victims would avert a mortal outcome by taking a daily pill to protect their heart.
It’s possible a red wine pill like Longevinex® could replace aspirin since half of the patients who experience a mortal heart seizure were taking aspirin on the day of their demise. Low-dose (81 mg) aspirin isn’t working, and high-dose (325 mg) aspirin produces offsetting side effects.
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November 9, 2010: by Bill Sardi
Las Vegas, NV (November 8, 2010) – According to the latest published research, the heart-healthiest laboratory animals in the world are taking Longevinex®, a red wine pill dietary supplement.
Researchers gave cholesterol-fed rabbits Longevinex®, a proprietary blend of red wine molecules (resveratrol, quercetin, ferulic acid) plus rice bran IP6 and vitamin D3, and found this dietary supplement:
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