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How the world got lost on
the road to an anti-aging pill
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June 11, 2010: by Bill Sardi
Say again? Pterostilbene? (pronounced “tero-STILL-bean”) If you take resveratrol pills you probably have never heard of pterostilbene, but it is a naturally-occurring, molecular look-alike of resveratrol.
Pterostilbene is alleged to be superior to resveratrol and the commercial availability of a pure form of pterostilbene (pTeroPure) is creating some manufacturer-driven hype that consumers should opt for it over resveratrol.
The actual development of pterostilbene as a raw material for dietary supplements began with research conducted by US Department of Agriculture scientists. Pterostilbene is derived from blueberries. It’s being imported from India as a nearly pure extract.
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May 31, 2010: by Bill Sardi
The consumer shift to buying dietary supplements online complicates the problem of sorting out fact from fiction when it comes to dietary supplements. The internet has become an unbridled field for electronic fraud when it comes to dietary supplements, and online consumers continue to be suckered in by the thousands on a daily basis. There are many reasons for this.
First, government overseers have chosen to look the other way while outlaw companies on the internet make unsubstantiated claims for their products. The Federal Trade Commission says it will do nothing unless it receives one-hundred consumer complaints and the Food and Drug Administration only sends toothless correction letters in regard to labeling or advertising claims. Online marketers of dietary supplements know there is no cop on supplement boulevard to issue citations.
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: by ResveratrolNews
Dr. William Li heads the Angiogenesis Foundation in Boston, a nonprofit that is re-conceptualizing global disease fighting. Dr. Li presents a new way to think about treating cancer and other diseases using molecules like resveratrol, which prevent the undesirable growth of new blood vessels that feed a tumor. The crucial first (and best) step: Eating cancer-fighting foods that cut off the supply lines and beat cancer at its own game. http://www.ted.com/talks/lang/eng/william_li.html
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May 25, 2010: by Bill Sardi
“Wine is the greatest of medicines. Where wine is lacking, drugs are necessary.” -The Talmud
That is the question posed to physicians in the Journal of the American Medical Association Journal in its May 26 online issue. (May 26, 2010; Vol. 303, No. 2065-73)
The response, written by an accomplished physician, is reflective of the widespread void in applying nutritional medicine in cases such as this one. The doctor is a bit ambiguous in his answer to this question and can never fully explain why the wine-drinking French exhibit far greater longevity and lean body mass compared to North Americans.
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May 17, 2010: by Bill Sardi
A month doesn’t go by these days that some researchers don’t discover another genetic pathway that promotes longevity. This time it’s about the PTEN gene, said to be a tumor suppressor gene. The more active the PTEN gene, and the less active the ARRESTIN gene, the longer roundworms lived. Roundworms without their ARRESTIN gene live about 30% longer. This research is published in the May 14 issue of the Journal of Biological Chemistry.
While investigators claim their research may lead to molecules that inhibit ARRESTIN and activate PTEN, such molecules have already been identified – namely molecules commonly found in red wine and soybeans — resveratrol, quercetin and genistein.
Resveratrol continues to astound. Resveratrol has many gene targets where it has been demonstrated to exert broad biological activity as an anti-inflammatory, anti-clotting, anti-cholesterol, anti-depressant, anti-viral, anti-fungal, anti-bacterial, anti-brain plaque (beta amyloid), anti-obesity agent. These properties must be safely demonstrated in humans with doses that are proven to be safe. – ©2010 Bill Sardi, exclusively for Reserveratrolnews.com
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: by Bill Sardi
A news story published in The London Times says so-called “Methuselah” genes have been found which increase the chance of living 100 years and beyond. An anti-aging pill is just 2 years away from being tested, says the report.
The report goes on to say that “the secret of longevity probably lies in have the right ‘suite’ of genes.” “Centenarians (those individuals who do live 100 years or more) have a high chance of having several such genes embedded in their DNA.” One researcher is quoted to say that “Longevity is strongly genetic and inherited.”
Can only those individuals fortunate enough to carry certain genes expect to live long? Might as well eat, drink and be merry, and live out the number of days your genes have destined you to live?
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May 13, 2010: by Bill Sardi
At a Royal Society conference this week in London, entitled “Turning Back the Clock,” pharmaceutical companies appeared to lay claim to the anti-aging pill market, saying such pills will begin human clinical study within two years or so. The conference drew worldwide headlines such as:
One news report said “Within a couple of generations living to be 100 could be as routine as collecting a bus pass is today. Some scientists go further and believe the first person to live to 150 may already have been born.”
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May 12, 2010: by Bill Sardi
That’s what Dr David Gems of the Institute of Healthy Ageing at University College London just said in the British paper THE TELEGRAPH. Dr. Gems says people will simply choose to end their own lives in the future, when anti-ageing drugs that could extend the human lifespan by many years, become commonplace.
Live much longer and set the timing for your last days of life? Would today’s “green” culture decide to make the perfect sustainable gift to the earth — their ashes turned into a renewable food — something someone once called Soylent Green?
Just how would that be accomplished — by such unoriginal ways as over-dosing on aspirin, or running a hose from the car tailpipe into the window and turning the engine on in the garage and then donating your body for pickup by the Soylent Green truck? Or rolling your wheelchair up to the Soylent Green processing plant yourself?
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May 5, 2010: by Bill Sardi
Consumers of resveratrol pills have certainly been taken for a ride in recent years, starting from anticipation that Harvard scientists had found the “holy grail” of aging in the SIrtuin1 gene, to the many other promises that the red wine molecule resveratrol is reported to offer. Come to find out, not only are research studies about the gene target of resveratrol in question, but that the first human study that gains widespread public attention is halted due to side effects.
But were the side effects produced by resveratrol in mega-doses (5000 mg per day), or by the toxic cancer drug (bortezomib)? Some subjects in the study were to have received resveratrol only, other subjects, resveratrol + bortezomib. Were the reported kidney side effects reported in both groups? The researchers haven’t been forthcoming about this as yet.
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April 29, 2010: by ResveratrolNews
A human study, conducted among adults in their 20s, shows that a single high-dose of resveratrol (250 or 500 milligram, 99% resveratrol, Biotivia) improves hemoglobin concentrations and delivery of oxygen to the brain, but did not improve “cognitive” (thinking) performance or allay mental fatigue. Researchers believe resveratrol activated nitric oxide gas which dilated (widened) blood vessels in the brain. The design and conclusions of study, conducted by British researchers, are brought into question because resveratrol is a copper chelator (key-lay-tor) and may over long-term use actually reduce hemoglobin levels and produce symptoms of fatigue and anemia. The higher (500 mg) dose used in this study was also shown in a prior animal experiment to slightly shorten lifespan. – Resveratrol News April 29, 2010
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