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October 29, 2009: by ResveratrolNews
The provision of high-dose resveratrol to laboratory mice not only cures many of them of metastatic (spreading) cancer, but produces complete immunity towards future cancer among surviving animals, even when tumor cells are intentionally re-injected into their bodies.
This astounding discovery has cancer researchers buzzing about a nutriceutical cancer vaccine that could revolutionize modern cancer therapy.
Researchers at the Department of Food Science, Chiayi University in Taiwan, injected laboratory mice twelve times with tumor cells which ended up in the lungs of the animals, mimicking metastatic colon cancer.
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August 29, 2009: by ResveratrolNews
Journal Comparative Physiology B (2008) 178:439–445
It may be difficult for humans to fathom that there is a African rodent that doesn’t age, is rarely ill, doesn’t get cancer, diabetes, or experience bone loss with advancing age, and whose females continuously produce babies and don’t experience a “change of life.” This tunneling rat outlives other rodents by ten fold. Your average pet lab rat lives ~3 years, this rodent 28-30 years!
Welcome to the world of the naked mole rat. Naked refers to its hairless pink skin.
Read the whole post »
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August 7, 2009: by ResveratrolNews
The Chicago Tribune report of a terminal cancer patient’s successful prolonged survival, credited to her use of a drug that inhibits the mTOR-gene pathway combined with “fresh-preserved” grapefruit juice, should have striking impact upon longevity seekers.
The reason? — The drug used to inhibit the mTOR gene pathway is rapamycin, recently heralded in the news media because it was found to significantly prolong (by 14%) the life of lab animals even though it was employed at a latter stage of their lifespan. [Nature. 2009 Jul 16;460(7253):392-5]
Rapamycin levels are so enhanced by grapefruit juice that once-weekly dosage produced drug concentrations equal to every-day dosing without juice.
Molecules in grapefruit juice are known to enhance the effects of drugs by inhibiting detoxification enzymes in the liver.
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August 4, 2009: by ResveratrolNews
Frank Weinberg and Navdeep S. Chandel, researchers at Northwestern University Medical School in Chicago, provide a profound new understanding of the role of reactive oxygen species in cases of cancer.
They report that tumor cells in lab dishes impair the production of p38, an inflammatory protein, and p53, an anti-cancer gene protein, to evade apoptosis (cell death) and for tumor generation to proceed.
In the diagram provided below these researchers distinguish reactive oxygen species (free radical generation) in normal cells vs tumor cells. In normal cells, low levels of oxygen free radicals can regulate controlled proliferation and growth via cell signaling whereas with high levels of free radicals induce cell death and senescence. Cancer cells with mutations in tumor suppressor genes (p53) can evade free radical generated cell death. Cancer cells exhibit high levels of free radicals leading to uncontrolled cellular proliferation (growth by rapid multiplication).
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August 2, 2009: by Bill Sardi
Researchers in France have conducted a striking experiment in animals to measure the chronobiological effects of resveratrol (rez-vair-ah-trawl), known as an antioxidant derived from red wine.
Chronobiology is a field of science that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar and lunar related rhythms. http://en.wikipedia.org/wiki/Chronobiology
Male rodents were administered resveratrol at three different dosages, equivalent to 56 mg, 140 mg and 350 mg, during light (day) and dark (night) periods and measurements of oxidation (TBARS- thiobarbituric acid reactive species) were conducted in heart, liver and kidney tissues.
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May 15, 2009: by ResveratrolNews
Vista, CA (May 13, 2009) – Roman soldiers wrapped their battle wounds in red wine and considered wine to be their best medicine. Over two-thousand years later, 88-year old Madeline May is just now catching on to what the Romans apparently knew centuries ago.
Madeline has been bed-ridden due to joint problems for many years now. With the aid of a walker she can barely hobble to the bathroom and back. Because of the pain, it takes about 5 minutes for her to stand erect. A trip to the bathroom and back is exhausting.
That was the “old” Madeline May. Today Madeline launches herself out of bed, is back in the kitchen washing dishes and doing house cleaning, and wants to take a trip to Montana to visit relatives. Madeline uses her walker now only out of habit. What brought about the sudden change?
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May 11, 2009: by ResveratrolNews
There are over 100 brands of resveratrol pills on the market, but only one is selling vigorously —ResV. And that is because of online fraud.
With the appearance of widespread interest in resveratrol in the aftermath of extolling report on CBS’ 60 Minutes, the Barbara Walters show and the Oprah show, budding entrepreneurs see an opportunity to add resveratrol to everything ranging from skin creams to bottled water. But the whole boom in resveratrol appears to be falsely created.
There was little public interest shown in resveratrol pills even after they were given glowing reports on CBS’ 60 Minutes, the Barbara Walters show and a go-ahead by Dr. Oz on the Oprah Winfrey TV show.
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May 10, 2009: by Bill Sardi
Something rather remarkable is happening in biological research. It involves study of reward centers in the brain and it spells promise for people who wish to overcome unhealthy habits such as tobacco use, alcohol over-consumption, dependency upon street drugs and even overeating.
A short course in how molecules affect the brain-reward centers is in order.
Brain cells have protein molecules on their surface (the plasma membrane) to which another molecule can be attached. This is called a cell receptor site. Molecules that attach to cell receptors are called ligands. Some of these ligands are hormones, nerve-transmitters (neurotransmitters), toxins, viruses, drugs, and molecules found in the diet.
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March 31, 2009: by Bill Sardi
It’s too enticing to resist. The offer has just arrived in your email — a free trial sample of a red wine pill that promises to extend human life, a pill that was endorsed by “Dr. Oz,” seen on Oprah and CBS’ 60 Minutes, and researched by leading universities and shown to cure cancer, Alzheimer’s, diabetes, control weight and eradicate wrinkles. And it’s free!
The cunning marketing program for ResV has overtaken every other brand of red wine resveratrol (rez-vair-aw-trawl) on the market. It’s an overnight sensation. Bloggers have piled on to gain affiliate fees and generate Google click fees so now there is an internet army of spammers and bloggers generating millions of dollars of sales per month, and more piling on daily.
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: by ResveratrolNews
For the first time researchers have demonstrated that relatively low doses of the red wine molecule resveratrol (rsz-vair-ah-trawl) reverse chemically-induced gastric ulcers in animals. Higher-doses of resveratrol delayed but did not prevent or reverse tissue damage.
Researchers induced gastric ulcers in laboratory animals by administering high doses of indomethacin, an anti-inflammatory drug known to irritate the gastric mucus lining. Mice were given resveratrol orally at different doses. The results were as follows:
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