Comprehensive Library Of Resveratrol News

While there has been much talk about Sirtuin-1 as the survival gene that is activated by life-prolonging calorie restriction, researchers report that Sirtuin-3 gene protein activates a protective internal antioxidant known as SOD-2 (superoxide dismutase-2) which in turn rejuvenates blood stem cells.  It was previously thought that DNA damage to old blood stem cells is irreversible, but this aging process (DNA damage) was reversed when Sirtuin-3 gene protein is produced.  Stem cells are unspecialized cells that can turn into heart, brain, muscle, nerve or other types of cells and are needed for repair of damaged cells and tissues.

The red wine molecule resveratrol is known to activate the Sirtuin-3 gene.  Longevinex, a branded resveratrol dietary supplement, has been shown to increase Sirtuin-3 gene protein 295% greater than plain resveratrol.  Read the abstract of the report below.

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In a landmark study, researchers have linked elevated blood-serum iron levels with shorter end caps (telomeres) on chromosomes.  Shorter telomere length is associated with increased incidence of age-related disease and mortality.  Telomere length has emerged as a marker for biological aging and is associated with shorter lifespan.

The results of this study may also help explain why telomere length is determined by gender as women have lower iron levels throughout most of life due to menstrual losses and are reported to have longer telomeres and a longer lifespan than males.

This study also points to interventions such as blood-letting and dietary avoidance of iron-rich foods to maintain telomeres and prolong human lifespan.

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European researchers report high-dose pure synthetic resveratrol produced no measurable benefit among healthy obese males over a 4-week trial.  It may be another nail in the coffin for resveratrol, but health journalist and resveratrol-pill formulator Bill Sardi says he thinks he knows why the study was a flop.

Certainly the world has been waiting for resveratrol to live up to its promise as a molecular mimic of a limited calorie diet.  In the animal laboratory, 40-50% reduction of calorie intake among warm-blood mammals about doubles their healthy lifespan.  Could this happen for humans?  The science has been mixed so far.  Sardi says he knows why.

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There is no question about it – Big Pharma and its minions of researchers are attempting to develop resveratrol analogs (look-alike molecules) that will garner billions in sales as a resveratrol-like drug.  The objective of the game is to patent a molecule that is alleged to exceed the biological activity of a natural molecule like resveratrol.

Some of the specific objectives are to improve resveratrol’s antioxidant activity, improve its anti-inflammatory properties, elevate its anti-viral activity, produce higher blood serum concentrations and greater stability, and increase its cancer cell-killing effect, etc.  Patents are being filed on improved resveratrol-like molecules.

But at the same time is Big Pharma attempting to disparage and subjugate resveratrol as a third-class molecule?

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