Comprehensive Library Of Resveratrol News

Well, that is oft repeated statement by mindless biologists who don’t really delve into this matter.  Technically they are correct.  Resveratrol is fully metabolized (taken out of action) after it has made a few passes through the liver (a process that can be delayed by taking quercetin with resveratrol).  Liver metabolism involves coupling resveratrol with detoxification molecules (sulfate, glucuronate) produced in the liver.  Resveratrol is then too large a molecule coupled to a carrier protein to pass through cells walls and influence genetic machinery inside cells.  However, an enzyme (glucuronidase) that is abundant at sites of inflammation, infection and malignancy unlocks resveratrol at the right time and place, freeing it to switch genes and act as an important copper-binding antioxidant.  The very fact resveratrol produces systemic-wide biological effects in compartmentalized organs such as the brain, heart, kidneys, suggests it is biologically active, even passing the blood-brain barrier.

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Bill Sardi Comments On New Genomic Anti-Cancer Drugs

The anticipation builds for anti-cancer drugs that target a broad array of genes that combat various types of cancer in different organs rather than a different drug for each cancer by their anatomical origin.  Instead of anti-cancer drugs for each organ, such as lung, prostate, breast and colon, geneticists now say new drugs in development may address many forms of cancer.

The first examples of this new thinking are studies published in the New England Journal of Medicine showing uterine cancer and leukemia have similar genetic fingerprints and could be treated by the same drug.  A large effort to this end is being commandeered at the Cancer Genome Atlas website.

However, the thinking is far too narrow now that geneticists know diseases are integrated via gene networks.  An online map can be viewed showing genes in many diseases overlap one another (note: it takes time to load).

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