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How the world got lost on
the road to an anti-aging pill
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January 22, 2018: by Bill Sardi
When scientific reports made front-page news headlines late in 2003 that the red wine molecule resveratrol, believed to be responsible for the French Paradox, triggered a survival gene that was known to be activated by a lifespan-doubling calorie restricted diet, hundreds of thousands of Americans began their own uncontrolled experiment to see if this was true.
For reference, the French Paradox was first posited on the CBS Sixty Minutes television show in 1991 when Dr. Serge Renaud of France reported the wine-drinking French had far lower mortality rates even though they consumed higher fat and cholesterol diets than North Americans. Dr. Renaud died in 2012 at the age of 85. His television report caused a temporary worldwide shortage of red wine.
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January 8, 2018: by Bill Sardi
Resveratrol is the elephant in the room when it comes to cancer. No single cancer drug has been developed with such broad anti-cancer activity. The anti-cancer qualities of resveratrol are summarized in a recent report published in the Annals of the New York Academy of Sciences.
Apart from its selective ability to kill cancer cells when delivered in high doses, there are many other beneficial properties of resveratrol that simply are untapped by modern oncology.
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: by Bill Sardi
Anyone who has had a heart attack or is at high risk for a heart attach should take a daily resveratrol pill. Heart muscle cells are slow regenerate after a heart attack. Dead cells become scar tissue that impairs the pumping power after a heart attack. A rationale for post heart attack resveratrol stem cell therapy is growing.
For the longest time it was thought the human heart had no regenerative capability. The discovery of endogenous stem cells harbored within human heart tissue in 2003 changed that thinking.
Stem cell therapy to replace scarred heart tissue following a heart attack has been a disappointment. The transplantation of stem cells into heart muscle tissue damaged by a heart attack is marginalized by the fact most engrafted stem cells fail to survive.
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January 4, 2018: by Bill Sardi
So many thoughts and emotions running through my head as I read Karen Wilder’s emotional statement released to ABC News about the ordeal of caring for her husband, actor Gene Wilder who succumbed to Alzheimer’s disease at age 83 in August of 2016.
Karen Wilder cites a striking statistic. A Stanford Medicine study that showed 40 percent of Alzheimer’s caregivers die before their patient, “not from disease, but from the sheer physical, spiritual and emotional toll of caring for a loved one with Alzheimer’s.”
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January 2, 2018: by Bill Sardi
In 2007 researchers first reported on the ability of the red wine molecule resveratrol (rez-vair-a-trol) to non-toxically kill cancer cells via release of calcium inside tumor cells.
Resveratrol induces release of calcium stores from a small protein-folding labyrinth inside living cells called the endoplasmic reticulum. Calcium concentration is higher within the endoplasmic reticulum than in the surrounding watery cytoplasm. A 3-to-4-fold increase in calcium was measured in one lab dish study using resveratrol. Calcium is then driven into the cell energy-producing mitochondria, which de-energizes them and further releases calcium back into the watery cytoplasm that eventually leads to tumor cell death. In laboratory animals some implanted tumors reverted back to their original size.
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December 29, 2017: by Bill Sardi
You can fool some of the people all of the time
and all of the people some of the time
but you can’t fool all of the people all of the time.
Except when it comes to calcium.
When it comes to preventing age-related bone loss, the obvious escapes attention. Osteoporosis or age-related bone loss largely occurring in females is due to a shortage of estrogen, not calcium as both doctors and consumers mistakenly believe. Because of this most trials fail to show supplemental calcium maintains bone density.
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December 28, 2017: by Bill Sardi
Researchers continue to piece together data to show that the lifespan and healthspan doubling effect of a calorie restricted diet observed in fruit flies, roundworms and laboratory mice, is applicable to humans.
Last year (2016) an extensive analysis concluded that the “health benefits of calorie restriction are conserved in monkeys and suggest that calorie restriction mechanisms are likely translatable to human health.”
And a team of researchers report that a two-year controlled trial of a calorie restricted diet in middle-aged humans concludes: “sustained calorie restriction is feasible in non-obese humans.”
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December 18, 2017: by Bill Sardi
It could be said that the “aging is optional” era began ~2003-2004 when geneticist David Sinclair of Harvard Medical School announced a connection between a life-doubling calorie restricted diet, the Sirtuin1 survival gene and the red wine molecule resveratrol (rez-vare-ah-trol).
Actually a decade earlier (1992) two researchers at Cornell University posited that resveratrol may be the active ingredient in wine that lowers circulating levels of cholesterol.
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December 11, 2017: by Bill Sardi
Biologists are re-thinking the origins of disease and aging. A compelling accumulation of data points to protein congestion inside a small organelle called the endoplasmic reticulum in living cells that accelerates aging and disease.
So let’s take a trip to the E.R. – the endoplasmic reticulum. The E.R. produces proteins and facilitates their passage through a tortuous pathway of tubules. In so doing, proteins must be properly folded to maintain health. Only properly folded proteins are allowed to exit the E.R. Otherwise they are degraded and expelled into the watery cytoplasm of the cell. Medical researchers now believe mis-folded proteins (also known as prions) in the E. R. are at the root of many diseases, particularly diseases of aging.
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November 8, 2017: by Bill Sardi
Nov. 7, 2017: The hope of a fountain of youth has been dashed forever. It was just days ago (October 30th) that researchers at the University of Arizona who study human aging said that it is mathematically impossible to halt or reverse the biological clock hands of time. Gone is the prospect of living young instead of growing old. The idea of an anti-aging pill is a pipe dream – like trying to catch the wind. It is biologically unattainable.
“There is logically, theoretically, mathematically no way out,” said a professor of evolutionary biology. Aging is inevitable.
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