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How the world got lost on
the road to an anti-aging pill
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March 8, 2018: by Bill Sardi
I’m of cataract age (in my early 70s). (cataract = cloudy focusing lens)
I’ve got clear lenses, no glaucoma (elevated fluid pressure); no other eye conditions typical for my age.
My retina scans you can see below.
My central retinal thickness is 255-256 right and left eye micrometers, about normal.
It would be typical for a 70+ year old to have drusen (oxysterol aka cholesterol) deposits at the back of my eyes. The scan below shows zero drusen.
My optic nerve and blood vessels are healthy.
I have habitually worn UV-blue-blocking sun lenses when outdoors during the day since age 40.
I have been supplementing my diet with lutein since 1992 when lutein first became available as a dietary supplement.
I take resveratrol since 2004 when it was popularized as an anti-aging molecule.
I have taken IP6 rice bran, an iron chelator, since the mid 1990s.
My vision is 20/30 in both eyes and I needed a prescription for astigmatism (irregular curvature of the front cornea of the eyes).
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February 26, 2018: by Bill Sardi
A recent report published in the journal Biomolecules and Therapeutics reveals the unparalleled ability of two natural molecules to address symptoms caused by diabetes.
Two natural molecules, quercetin and resveratrol, when used together are being extolled for their synergistic ability to quell the metabolic problems posed by diabetes and the drugs used to treat the disease. Undesirable side effects that accompany most anti-diabetic drugs (weight gain, low-blood sugar and death of insulin-making cells in the pancreas) as well as complications in other organs (kidneys and liver) prompt researchers to search for less problematic alternatives.
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February 20, 2018: by Bill Sardi
From the land down under, Australians are becoming acclimated to an idea brought to a present reality by one of their own – geneticist David Sinclair at Harvard Medical School. Dr. Sinclair says to reporters with the Financial Review that: “Living To 150 Will Revolutionize Markets” as if it is a development that is just around the corner. Imagine the profound financial let alone human implications of a 150-year lifespan.
Dr. Sinclair says within our lifetimes it is likely humans may creep in small increments towards commonly living beyond 100 years.
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January 22, 2018: by Bill Sardi
When scientific reports made front-page news headlines late in 2003 that the red wine molecule resveratrol, believed to be responsible for the French Paradox, triggered a survival gene that was known to be activated by a lifespan-doubling calorie restricted diet, hundreds of thousands of Americans began their own uncontrolled experiment to see if this was true.
For reference, the French Paradox was first posited on the CBS Sixty Minutes television show in 1991 when Dr. Serge Renaud of France reported the wine-drinking French had far lower mortality rates even though they consumed higher fat and cholesterol diets than North Americans. Dr. Renaud died in 2012 at the age of 85. His television report caused a temporary worldwide shortage of red wine.
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January 8, 2018: by Bill Sardi
Resveratrol is the elephant in the room when it comes to cancer. No single cancer drug has been developed with such broad anti-cancer activity. The anti-cancer qualities of resveratrol are summarized in a recent report published in the Annals of the New York Academy of Sciences.
Apart from its selective ability to kill cancer cells when delivered in high doses, there are many other beneficial properties of resveratrol that simply are untapped by modern oncology.
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: by Bill Sardi
Anyone who has had a heart attack or is at high risk for a heart attach should take a daily resveratrol pill. Heart muscle cells are slow regenerate after a heart attack. Dead cells become scar tissue that impairs the pumping power after a heart attack. A rationale for post heart attack resveratrol stem cell therapy is growing.
For the longest time it was thought the human heart had no regenerative capability. The discovery of endogenous stem cells harbored within human heart tissue in 2003 changed that thinking.
Stem cell therapy to replace scarred heart tissue following a heart attack has been a disappointment. The transplantation of stem cells into heart muscle tissue damaged by a heart attack is marginalized by the fact most engrafted stem cells fail to survive.
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January 4, 2018: by Bill Sardi
So many thoughts and emotions running through my head as I read Karen Wilder’s emotional statement released to ABC News about the ordeal of caring for her husband, actor Gene Wilder who succumbed to Alzheimer’s disease at age 83 in August of 2016.
Karen Wilder cites a striking statistic. A Stanford Medicine study that showed 40 percent of Alzheimer’s caregivers die before their patient, “not from disease, but from the sheer physical, spiritual and emotional toll of caring for a loved one with Alzheimer’s.”
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January 2, 2018: by Bill Sardi
In 2007 researchers first reported on the ability of the red wine molecule resveratrol (rez-vair-a-trol) to non-toxically kill cancer cells via release of calcium inside tumor cells.
Resveratrol induces release of calcium stores from a small protein-folding labyrinth inside living cells called the endoplasmic reticulum. Calcium concentration is higher within the endoplasmic reticulum than in the surrounding watery cytoplasm. A 3-to-4-fold increase in calcium was measured in one lab dish study using resveratrol. Calcium is then driven into the cell energy-producing mitochondria, which de-energizes them and further releases calcium back into the watery cytoplasm that eventually leads to tumor cell death. In laboratory animals some implanted tumors reverted back to their original size.
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December 29, 2017: by Bill Sardi
You can fool some of the people all of the time
and all of the people some of the time
but you can’t fool all of the people all of the time.
Except when it comes to calcium.
When it comes to preventing age-related bone loss, the obvious escapes attention. Osteoporosis or age-related bone loss largely occurring in females is due to a shortage of estrogen, not calcium as both doctors and consumers mistakenly believe. Because of this most trials fail to show supplemental calcium maintains bone density.
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December 28, 2017: by Bill Sardi
Researchers continue to piece together data to show that the lifespan and healthspan doubling effect of a calorie restricted diet observed in fruit flies, roundworms and laboratory mice, is applicable to humans.
Last year (2016) an extensive analysis concluded that the “health benefits of calorie restriction are conserved in monkeys and suggest that calorie restriction mechanisms are likely translatable to human health.”
And a team of researchers report that a two-year controlled trial of a calorie restricted diet in middle-aged humans concludes: “sustained calorie restriction is feasible in non-obese humans.”
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