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December 15, 2015: by Bill Sardi
Given the assumption humanity is not going to deprive itself of food to live an extra 40-50 healthy years (healthspan and lifespan doubles among calorie restricted animals), biological short cuts in the form of molecular mimics of calorie restriction appear more practical. Widespread use of properly dosed small molecules could achieve super-longevity only rivaled by the Biblical patriarchs.
Mild biological stress activates cellular defenses. Small molecules, as presented here, that can pass through cell walls and enter the nucleus and favorably influence genetic machinery are abundant in nature. Cells with a mass of less tan 100 nanometers (billion of a meter) in one direction can absorb molecules and pass through the blood/ brain barrier. [Nanomedicine 2011] Many natural molecules already are smaller than 100 nanometers and don’t require nanosizing to enter cells. [Knowledge of Health]
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October 26, 2015: by Bill Sardi
1000 AD: — “Here, eat this herb.”
1700 AD: — “That herb is an old wives’ tale; take this elixir.”
1900 AD: — “That elixir is quackery; take this pill.”
1960 AD: — “That pill doesn’t do any good; take this antibiotic.”
2015 AD: — “That antibiotic isn’t safe; take this herb.”
Modern medicine has reveled for over a decade in the most stupendous advancement in the history of cancer therapy, a drug discovery that added decades to the lives of patients with chronic myelogenous leukemia (CML) via a gene-targeted enzyme inhibitor. CML is the most common form of leukemia with around 5000 new cases diagnosed annually.
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October 19, 2015: by Bill Sardi
East Indian-born, University of Connecticut researcher Dipak Das PhD (deceased) has become a poster boy for scientific fraud.Or was the witch-hunt launched against him a fraud in itself?
In 2012 popular radio show host Rush Limbaugh announced that Dr. Das “made it all up,” that is, all the science he published to show that the red wine molecule resveratrol protects the heart from damage before a heart attack occurs, considered the best form of cardio-protection said Dipak Das at the time.
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October 14, 2015: by Bill Sardi
Bring on the wheat germ. Come to find it is loaded with a polyamine molecule that prolongs the lifespan of many life forms including mammals when supplemented in the diet. That molecule is abundantly found in wheat germ.
Polyamines are identified as putrescine, spermine and spermidine. They are synthesized internally from the amino acid ornithine. Polyamines are also consumed in the diet and play an important role in regulation of cell growth and immune response. [Nutrition 2007]
Biologists excitedly say polyamines found in many foods may reset the body’s 24-hour circadian clock and prolong the healthspan and lifespan of humans. [Cell Metabolism 2015]
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September 7, 2015: by Bill Sardi
On the heels of submission for an FDA-approved trial of what may become the first FDA-approved anti-aging pill [ResveratrolNews June 22, 2015] comes word that scientists have developed gene chip technology that can rapidly analyze a blood sample to distinguish biological age from chronological (calendar) age in humans. [Daily Mail UK Sept 6, 2015]
The technology was not confined to lab animals but rather was proven in humans, which suggests it could become available as early as next year and have immediate application to help identify healthy organ donors and to establish life and health insurance rates. [Genome Biology Volume 16, Sept 2015]
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September 2, 2015: by Bill Sardi
To: Jessica Aschemann-Witzel,
MAPP Centre—Research on Value Creation in the Food Sector,
Aarhus University, Aarhus, Denmark. jeaw@badm.au.dk
From: Bill Sardi, Resveratrol Partners LLC, Las Vegas, NV (www.Longevinex.com)
After reading the report entitled “Resveratrol and health from a consumer perspective” as published in the August 2015 issue of the Annals of the New York Academy of Sciences (abstract at bottom), I offer the following comments:
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August 27, 2015: by Bill Sardi
Today’s news headlines once again attribute recent declines in coronary heart disease mortality to statin drugs and modern treatments like arterial stents.
Citing a report in the European Heart Journal, The Daily Mail, a British publication, mistakenly claims Great Britain has “one of the best records in Europe” with 184 deaths per 100,000 people for coronary heart disease — a dramatic 46.9% decline over the past 10 years. [European Heart Journal Aug 25, 2015; Daily Mail UK Aug 26, 2015] Yet the chart below reveals Great Britain (United Kingdom) isn’t even in the top 10 countries with the lowest death rate for coronary artery disease.
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August 16, 2015: by Bill Sardi
No, one doesn’t have to be courageous to take resveratrol supplements but researchers report, for the first time, that resveratrol may embolden those who fortify their diet with it.
Researchers have created a fearless super-intelligent mouse in the laboratory by alteration of a single gene. This was accomplished, not by alteration of the structure of a gene or repair of a gene mutation but by epigenetic inhibition of a protein (an enzyme) that is produced by this gene.
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August 7, 2015: by Bill Sardi
In recent years longevity seekers have become enthralled with the idea of maintaining the end caps of their chromosomes, called telomeres) to live successfully past the age of 100. Now researchers say control of chronic low-grade inflammation is predictive of healthy aging and telomere length is not. [Ebiomedicine Aug 5, 2015]
When super-longevity is passed on to children of super-centenarians they do so via control over low-grade inflammation that results in telomere maintenance – at age 80 their telomeres are like 60-year olds. [Medicalxpress Aug 5, 2015]
Chronic low-grade inflammation is associated with risk of death, loss of mental capacity and loss of independent living.
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July 24, 2015: by Bill Sardi
The answer to the above question is “we may never know.” Big Pharma’s and Modern Medicine’s mantra is that the use of herbal supplements is unproven. Yes, but will they ever put resveratrol to the test in human studies? Resveratrol has not been disproven as a GLP-1 activator in humans. It was shown to activate glucagon-like peptide-1 in an animal study. [PLoS One June 6, 2011]
The publicity machines behind the drug companies herald the “discovery” of a stop-eating hormone, glucagon-like peptide-1.
[Daily Mail UK July 23, 2015] But GLP-1 was first described in the 1980s. So GLP-1 is not new. In fact, there are already three GLP-1 drugs on the market.
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