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May 7, 2011: by Bill Sardi
Researchers in Sweden report that a single dose of resveratrol combined with a platinum-based anti-cancer drug prevented resurgence of ovarian cancer in a laboratory dish. This finding is quite extraordinary given that relapse of ovarian cancer following platinum-based drug therapy (cisplatin, carboplatin) is common and 5-year survival for this type of cancer is only 40-45%.
Resveratrol allowed investigators to use low-dose chemotherapy.
A picture of tumor cell growth after 3 days is shown here (below).
The platinum + resveratrol treated tumor cells could not resume growth. Tumor cells treated with platinum drugs alone or resveratrol alone resumed growth.
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April 7, 2011: by Bill Sardi
At this point in time, April 2011, going on seven years since resveratrol was first heralded on the front page of The New York Times, progress in resveratrol research has been slow and there has been virtually no adoption of this molecule into the armamentarium of modern medicine, despite it being one of the most powerful molecules uncovered in nature.
So far, according to a report published in Wine Spectator entitled “Resveratrol Science Hits A Wall,” resveratrol has not been shown to be a fountain of youth in animal studies. Of course, human longevity studies would provide conclusive evidence but are impractical due to the many decades they would take to complete.
After reviewing over 100 studies, leading resveratrol researcher Dipak Das PhD, of the University of Connecticut, says there is no scientific basis to date to call resveratrol a fountain of youth. In fact, the most convincing evidence for resveratrol is provided within the context of the Mediterranean diet, taken with a meal and red wine, which is a concentrated but low-dose source of resveratrol.
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March 22, 2011: by Bill Sardi
The life of Joyce H. Brown has been chronicled on her website, www.griefrelief.org.
Interested parties can read her whole life story there, which tells of her life-long health challenges, which include inexplicable maladies that even perplexed her doctors, chronic injuries emanating for many auto accidents, and even a near-death experience. And then her house burned to the ground. The sum of these experiences resulted in Dr. Joyce writing a popular book entitled Heavenly Answers For Earthly Challenges (initially self-published in 1997 and demand for copies continue.)
With the writing of that book, Dr. Joyce began to receive phone calls from many desperate people around the world, some who were contemplating the idea of intentionally ending their lives. Since then Dr. Joyce has counseled many people to hold onto life rather than end it.
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March 20, 2011: by Bill Sardi
GlaxoSmithKline (Sirtris Pharmaceuticals) may have abandoned further research on its SRT501 resveratrol pill, but that hasn’t dampened ongoing research of this red wine molecule.
Researchers in Australia now say there are a “plethora of laboratory investigations which provide evidence for the multi‐faceted properties of resveratrol and suggest that resveratrol may target ageing and obesity-related chronic disease by regulating inflammation and oxidative stress.”
Researchers at the University of Queensland (Australia) say the first in vitro (lab dish) and in vivo (living organisms) scientific evidence has certainly confirmed a role for nutra-pharmacology in health.
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March 19, 2011: by Bill Sardi
Knowledge of Health, Inc. (March 18, 2011) – Researchers at the Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, now explain how an imbalance in estrogen metabolism leads to improper repair of broken DNA which in turn produces gene mutations that promote breast, prostate and other cancers.
These researchers then go on to identify two natural molecular antidotes, a sulfur compound (N-acetyl cysteine) and a molecule found in red wine (resveratrol), which can completely block the initiation of these cancers. Both of these molecules are widely available as dietary supplements. When used together these antioxidants completely abolished the formation of DNA-adducts (cancer-causing chemicals that are coupled with DNA), which is the initiating step in these cancers.
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March 8, 2011: by Bill Sardi
First-Person Accounts Of Longevinex® Users Parallel Survival Mechanisms First Described By Biologist Felix Z. Meerson MD
The human organism must be endowed with
efficient specialized mechanisms that limit
the reaction to stress and prevent stress damage.
— Felix Z. Meerson MD, 1991
Longevinex® users have begun to provide evidence for an exceptional biological phenomenon first described by Felix Z. Meerson MD. Their accounts of super-human health are provided within the following text of this report.
A great difficulty here is in crafting words that sound believable in describing this extraordinary biological phenomenon over plain advertising hype.
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February 23, 2011: by Bill Sardi
There is a very simple measure for any new potential therapy for enhanced longevity: is it either (a) doing at least as well as calorie restriction in mice when it comes to health and longevity, or (b) achieving important results that calorie restriction cannot show in mice – such as outright rejuvenation. The popular supplement resveratrol fails miserably to achieve significant results in either of these goals after more than five years of experimentation and hundreds of millions of dollars in research funding. This means that it is a dead end, or so close to one as makes no real difference. The only value gained lies in incremental improvements in the understanding of metabolism – which could have been achieved while studying more effective paths to the same end goal.
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February 20, 2011: by Bill Sardi
ResveratrolNews.com – Health news headlines today question whether human growth hormone replacement, used by many Americans to overcome the ravages of aging, is just a misdirection.
It is true that the secretion of human growth hormone diminishes with advancing age. But the just-released results of a 22-year study involving a population of genetically-abnormal individuals in Ecuador who produce low amounts of human growth hormone (GHG) and insulin-like growth factor (IGF) reveals this group exhibit no diabetes, almost no cancer and a very low rate of stroke. Strikingly, the blood serum of these people exhibits a double-protective effect: it protects against oxidative damage and gene mutations and also promotes cellular suicide among highly damaged cells.
Laboratory animals, bred to produce low amounts of these hormones, live on average about 30-40% longer. In human terms, that would thrust human populations toward 100-plus-year life spans. Theoretically, humans who produce an insufficient amount of growth hormones should have what is called a square survival curve where most of life is lived without major illness and then you drop dead, said one of the primary researchers involved in the study.
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February 1, 2011: by ResveratrolNews
Erectile dysfunction is a sign of poor circulation and/or high blood sugar which many men depressingly face. Selling at prices up to $18 a pill online, Viagra is the best known pill that induces blood vessels in the penis to widen (dilate) and harden the male organ. Cialis and Levitra are other widely-promoted brands of male potency pills. In the animal laboratory, elevated blood sugar was chemically induced to produce erectile dysfunction and then vardenafil (Levitra) was compared against resveratrol, a widely available herbal supplement that is known to dilate blood vessels in the same manner. Resveratrol was comparable to vardenafil and when both were used there was greater effect. The biggest advantage for resveratrol is that it has many other health benefits. Source: Jan 26, 2011 release at the Journal of Sexual Medicine – ResveratrolNews.com
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: by Bill Sardi
It was Felix Z. Meerson MD, of the Soviet Academy of Medical Sciences, who in the 1980s began to suggest that the heart could be protected from damage caused from a heart attack by mild amounts of biological stress prior to the event. Dr. Meerson even went so far as to subject animals after a heart attack to low-oxygen (high-altitude) environments which led to complete recovery from heart muscle spasms and a two-fold reduction in scarred tissue.
The most obvious application of cardiac pre-conditioning would be in surgery. The surgical table or immediate post-surgical mortality rate for coronary artery bypass surgery and heart valve surgery is roughly ~3% and 5% respectively.
An effort to pre-condition the heart to withstand temporary mild restriction of oxygenated blood is facilitated by application of tourniquets (blood pressure cuff) to extremities (the thighs) prior to the operating table. This is called remote ischemic preconditioning. It is used successfully prior to bypass and heart valve surgery. So it is not like cardiology is totally ignoring preconditioning.
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