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November 28, 2010: by Bill Sardi
Eugene D. Weinberg PhD is emeritus professor in biology at Indiana University and long-time authority on iron overload. His recent landmark paper, entitled The Hazards Of Iron Loading, published in the November issue of Metallomics (Volume 2, pages 732–740, 2010), provides authoritative evidence for the predominant role of iron in human aging.
Consider some of the striking facts that Dr. Weinberg presents in his report:
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November 20, 2010: by Bill Sardi
Comment: for all resveratrol-followers out there, researchers find that activation of the 5-lipoxygenase gene is key to the formation of beta amyloid plaque formation in the brain, thought to be involved in Alzheimer’s disease. While there is no available drug specifically designed to inhibit 5-lipoxygenase, resveratrol, a natural enzyme inhibitor and metal (copper) chelator, inhibits 5-lipoxygenase.
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November 19, 2010: by Bill Sardi
Mice lacking the Sirtuin3 gene develop hearing loss via the production of free radicals that damage the power plants (mitochondria) within living cells, said researchers in a newly published report in the journal CELL today.
Researchers report the Sirtuin3 gene is essential in producing the health and longevity effects of a limited calorie diet. The Sirtuin3 gene increases antioxidant activity (glutathione, pronounced glu-tah-thigh-on) in mitochondrial compartments within living cells, thus preventing age-related hearing loss. The mitochondria are small organelles that a found within living cells that produce cellular energy in the form of adenosine triphosphate (ATP).
So far Sirtuin3 has taken a back seat to Sirtuin1 in longevity research, but possibly the entire family of Sirtuin “survival genes” will eventually be linked to longevity mechanisms. The entire research report can be viewed here.
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November 18, 2010: by Bill Sardi
In a feature article appearing in Australian Life Scientist entitled “The Science of Longevity: Resveratrol and Beyond,” Harvard biologist and longevity researcher David Sinclair PhD, whose research studies involving the activation of the Sirtuin1 longevity gene by the red wine molecule resveratrol have been recently called into question, now says he will soon reveal a “protein partner that is part of the mechanism,” a protein which explains why resveratrol works in some laboratory studies and not in others.
The article in Life Scientist says Sinclair is keeping the details of this protein partner “close to his chest,” he will be revealing it at the Australian Health & Medical Research Congress now underway. Sinclair says “We’ve found the missing piece to the puzzle that will make sense of all the data they’re arguing about, a piece people haven’t realized was missing…. People didn’t know you need to add it for it to be physiologically relevant.”
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November 16, 2010: by Bill Sardi
Las Vegas, NV (Nov. 16, 2010) – University-based researchers report today in the Canadian Journal of Physiology & Pharmacology that a resveratrol-based nutriceutical (Longevinex®) induces longevity effects at low dose in laboratory animals.
Also, as expected, Longevinex® (pronounced long-jev-in-ex) limited damage to the heart after an intentionally-induced heart attack. Longevinex® reduced the size of the experimentally-induced heart attack from 37% to 23% of heart tissue, sufficient for the heart to survive this adverse event. There was markedly less scar tissue (fibrosis) following the heart attack. If the results of this animal study are applicable to humans, many thousands of heart-attack victims would avert a mortal outcome by taking a daily pill to protect their heart.
It’s possible a red wine pill like Longevinex® could replace aspirin since half of the patients who experience a mortal heart seizure were taking aspirin on the day of their demise. Low-dose (81 mg) aspirin isn’t working, and high-dose (325 mg) aspirin produces offsetting side effects.
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November 9, 2010: by Bill Sardi
Las Vegas, NV (November 8, 2010) – According to the latest published research, the heart-healthiest laboratory animals in the world are taking Longevinex®, a red wine pill dietary supplement.
Researchers gave cholesterol-fed rabbits Longevinex®, a proprietary blend of red wine molecules (resveratrol, quercetin, ferulic acid) plus rice bran IP6 and vitamin D3, and found this dietary supplement:
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October 28, 2010: by Bill Sardi
A molecule extracted from the botanical herb Astragalus is now being widely touted as a “youth preserver.” One advocate calls it “the most exciting breakthrough in the last century.” Theoretically, how does this molecule do this? Answer: By lengthening the age-shortened end caps of chromosomes called telomeres.
A published human study claims those subjects who took the Astragalus extract called TA-65 had cells that were 5-20 years younger. TA-65 activates the gene that produces telomerase, the natural enzyme that repairs fragmented telomeres.
There always a kernel of truth to such claims, but in this instance there is also a lot of stretching the truth too.
Telomeres are known as the biological clock of the cell, since they shorten with each cell division and with advancing age. Shortened telomeres is claimed to govern the rate of aging. Telomere lengthening agents like Astragalus extracts would theoretically slow aging.
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: by Bill Sardi
Derived from the medical literature and from reports by consumers to manufacturers.
Symptoms believed to be related to over-inhibition of TNF (tumor necrosis factor)
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October 17, 2010: by Bill Sardi
A published report in the Canadian Journal of Physiology and Pharmacology (Volume 88, pages 1017-1025) today confirms that Longevinex® is the first branded resveratrol-based dietary supplement shown to exhibit cardio-protection, that is, it preconditions the heart so if a future heart attack occurs, the patient (in this instance, a laboratory rat) won’t succumb to this unexpected event. An abstract of the report can be viewed online (click here), and the full paper is also available for free public viewing (PDF version / HTML version)
The experiment showed that Longevinex®, a multi-ingredient nutriceutical that provides resveratrol in a matrix with quercetin, rice bran phytate, ferulic acid and vitamin D3, exerts cardio-protective action equivalent to that produced by plain resveratrol at a dose 40% lower than prior published studies (175 mg resveratrol, 100 mg resveratrol/Longevinex matrix).
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October 14, 2010: by Bill Sardi
Source: Med Hypotheses. 2010 Oct 5. [Epub ahead of print]
Mannari C, Bertelli AA, Stiaccini G, Giovannini L.Department of Neuroscience, Pharmacology Section, University of Pisa, Pisa, Italy.
Researchers in Italy report that inexpensive, diluted wine activates the Sirtuin1 survival gene better than pure resveratrol. The study was conducted to determine the potential health effects afforded by table wine made from Lambrusco grapes.
An errant study published in 2003, researchers showed that resveratrol is the small molecule that most effectively activates the Sirtuin1 gene among all small molecules tested. The Sirtuin1 gene is akin to the SIR2 gene in lower life forms (yeast cells, roundworms, fruit flies) and is portrayed as the key gene that is activated by a limited calorie diet, a practice that unequivocally doubles the lifespan of all living organisms.
However, it was discovered that the fluorescent compound used in the 2003 assay is what activated Sirtuin1, not resveratrol, thus obfuscating the gene target of this red wine molecule.
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