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How the world got lost on
the road to an anti-aging pill
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May 17, 2010: by Bill Sardi
A month doesn’t go by these days that some researchers don’t discover another genetic pathway that promotes longevity. This time it’s about the PTEN gene, said to be a tumor suppressor gene. The more active the PTEN gene, and the less active the ARRESTIN gene, the longer roundworms lived. Roundworms without their ARRESTIN gene live about 30% longer. This research is published in the May 14 issue of the Journal of Biological Chemistry.
While investigators claim their research may lead to molecules that inhibit ARRESTIN and activate PTEN, such molecules have already been identified – namely molecules commonly found in red wine and soybeans — resveratrol, quercetin and genistein.
Resveratrol continues to astound. Resveratrol has many gene targets where it has been demonstrated to exert broad biological activity as an anti-inflammatory, anti-clotting, anti-cholesterol, anti-depressant, anti-viral, anti-fungal, anti-bacterial, anti-brain plaque (beta amyloid), anti-obesity agent. These properties must be safely demonstrated in humans with doses that are proven to be safe. – ©2010 Bill Sardi, exclusively for Reserveratrolnews.com
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: by Bill Sardi
A news story published in The London Times says so-called “Methuselah” genes have been found which increase the chance of living 100 years and beyond. An anti-aging pill is just 2 years away from being tested, says the report.
The report goes on to say that “the secret of longevity probably lies in have the right ‘suite’ of genes.” “Centenarians (those individuals who do live 100 years or more) have a high chance of having several such genes embedded in their DNA.” One researcher is quoted to say that “Longevity is strongly genetic and inherited.”
Can only those individuals fortunate enough to carry certain genes expect to live long? Might as well eat, drink and be merry, and live out the number of days your genes have destined you to live?
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May 13, 2010: by Bill Sardi
At a Royal Society conference this week in London, entitled “Turning Back the Clock,” pharmaceutical companies appeared to lay claim to the anti-aging pill market, saying such pills will begin human clinical study within two years or so. The conference drew worldwide headlines such as:
One news report said “Within a couple of generations living to be 100 could be as routine as collecting a bus pass is today. Some scientists go further and believe the first person to live to 150 may already have been born.”
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May 12, 2010: by Bill Sardi
That’s what Dr David Gems of the Institute of Healthy Ageing at University College London just said in the British paper THE TELEGRAPH. Dr. Gems says people will simply choose to end their own lives in the future, when anti-ageing drugs that could extend the human lifespan by many years, become commonplace.
Live much longer and set the timing for your last days of life? Would today’s “green” culture decide to make the perfect sustainable gift to the earth — their ashes turned into a renewable food — something someone once called Soylent Green?
Just how would that be accomplished — by such unoriginal ways as over-dosing on aspirin, or running a hose from the car tailpipe into the window and turning the engine on in the garage and then donating your body for pickup by the Soylent Green truck? Or rolling your wheelchair up to the Soylent Green processing plant yourself?
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May 5, 2010: by Bill Sardi
Consumers of resveratrol pills have certainly been taken for a ride in recent years, starting from anticipation that Harvard scientists had found the “holy grail” of aging in the SIrtuin1 gene, to the many other promises that the red wine molecule resveratrol is reported to offer. Come to find out, not only are research studies about the gene target of resveratrol in question, but that the first human study that gains widespread public attention is halted due to side effects.
But were the side effects produced by resveratrol in mega-doses (5000 mg per day), or by the toxic cancer drug (bortezomib)? Some subjects in the study were to have received resveratrol only, other subjects, resveratrol + bortezomib. Were the reported kidney side effects reported in both groups? The researchers haven’t been forthcoming about this as yet.
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April 29, 2010: by ResveratrolNews
A human study, conducted among adults in their 20s, shows that a single high-dose of resveratrol (250 or 500 milligram, 99% resveratrol, Biotivia) improves hemoglobin concentrations and delivery of oxygen to the brain, but did not improve “cognitive” (thinking) performance or allay mental fatigue. Researchers believe resveratrol activated nitric oxide gas which dilated (widened) blood vessels in the brain. The design and conclusions of study, conducted by British researchers, are brought into question because resveratrol is a copper chelator (key-lay-tor) and may over long-term use actually reduce hemoglobin levels and produce symptoms of fatigue and anemia. The higher (500 mg) dose used in this study was also shown in a prior animal experiment to slightly shorten lifespan. – Resveratrol News April 29, 2010
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October 29, 2009: by ResveratrolNews
The provision of high-dose resveratrol to laboratory mice not only cures many of them of metastatic (spreading) cancer, but produces complete immunity towards future cancer among surviving animals, even when tumor cells are intentionally re-injected into their bodies.
This astounding discovery has cancer researchers buzzing about a nutriceutical cancer vaccine that could revolutionize modern cancer therapy.
Researchers at the Department of Food Science, Chiayi University in Taiwan, injected laboratory mice twelve times with tumor cells which ended up in the lungs of the animals, mimicking metastatic colon cancer.
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August 29, 2009: by ResveratrolNews
Journal Comparative Physiology B (2008) 178:439–445
It may be difficult for humans to fathom that there is a African rodent that doesn’t age, is rarely ill, doesn’t get cancer, diabetes, or experience bone loss with advancing age, and whose females continuously produce babies and don’t experience a “change of life.” This tunneling rat outlives other rodents by ten fold. Your average pet lab rat lives ~3 years, this rodent 28-30 years!
Welcome to the world of the naked mole rat. Naked refers to its hairless pink skin.
Read the whole post »
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August 7, 2009: by ResveratrolNews
The Chicago Tribune report of a terminal cancer patient’s successful prolonged survival, credited to her use of a drug that inhibits the mTOR-gene pathway combined with “fresh-preserved” grapefruit juice, should have striking impact upon longevity seekers.
The reason? — The drug used to inhibit the mTOR gene pathway is rapamycin, recently heralded in the news media because it was found to significantly prolong (by 14%) the life of lab animals even though it was employed at a latter stage of their lifespan. [Nature. 2009 Jul 16;460(7253):392-5]
Rapamycin levels are so enhanced by grapefruit juice that once-weekly dosage produced drug concentrations equal to every-day dosing without juice.
Molecules in grapefruit juice are known to enhance the effects of drugs by inhibiting detoxification enzymes in the liver.
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August 4, 2009: by ResveratrolNews
Frank Weinberg and Navdeep S. Chandel, researchers at Northwestern University Medical School in Chicago, provide a profound new understanding of the role of reactive oxygen species in cases of cancer.
They report that tumor cells in lab dishes impair the production of p38, an inflammatory protein, and p53, an anti-cancer gene protein, to evade apoptosis (cell death) and for tumor generation to proceed.
In the diagram provided below these researchers distinguish reactive oxygen species (free radical generation) in normal cells vs tumor cells. In normal cells, low levels of oxygen free radicals can regulate controlled proliferation and growth via cell signaling whereas with high levels of free radicals induce cell death and senescence. Cancer cells with mutations in tumor suppressor genes (p53) can evade free radical generated cell death. Cancer cells exhibit high levels of free radicals leading to uncontrolled cellular proliferation (growth by rapid multiplication).
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