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How the world got lost on
the road to an anti-aging pill
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May 12, 2010: by Bill Sardi
That’s what Dr David Gems of the Institute of Healthy Ageing at University College London just said in the British paper THE TELEGRAPH. Dr. Gems says people will simply choose to end their own lives in the future, when anti-ageing drugs that could extend the human lifespan by many years, become commonplace.
Live much longer and set the timing for your last days of life? Would today’s “green” culture decide to make the perfect sustainable gift to the earth — their ashes turned into a renewable food — something someone once called Soylent Green?
Just how would that be accomplished — by such unoriginal ways as over-dosing on aspirin, or running a hose from the car tailpipe into the window and turning the engine on in the garage and then donating your body for pickup by the Soylent Green truck? Or rolling your wheelchair up to the Soylent Green processing plant yourself?
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May 5, 2010: by Bill Sardi
Consumers of resveratrol pills have certainly been taken for a ride in recent years, starting from anticipation that Harvard scientists had found the “holy grail” of aging in the SIrtuin1 gene, to the many other promises that the red wine molecule resveratrol is reported to offer. Come to find out, not only are research studies about the gene target of resveratrol in question, but that the first human study that gains widespread public attention is halted due to side effects.
But were the side effects produced by resveratrol in mega-doses (5000 mg per day), or by the toxic cancer drug (bortezomib)? Some subjects in the study were to have received resveratrol only, other subjects, resveratrol + bortezomib. Were the reported kidney side effects reported in both groups? The researchers haven’t been forthcoming about this as yet.
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April 29, 2010: by ResveratrolNews
A human study, conducted among adults in their 20s, shows that a single high-dose of resveratrol (250 or 500 milligram, 99% resveratrol, Biotivia) improves hemoglobin concentrations and delivery of oxygen to the brain, but did not improve “cognitive” (thinking) performance or allay mental fatigue. Researchers believe resveratrol activated nitric oxide gas which dilated (widened) blood vessels in the brain. The design and conclusions of study, conducted by British researchers, are brought into question because resveratrol is a copper chelator (key-lay-tor) and may over long-term use actually reduce hemoglobin levels and produce symptoms of fatigue and anemia. The higher (500 mg) dose used in this study was also shown in a prior animal experiment to slightly shorten lifespan. – Resveratrol News April 29, 2010
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October 29, 2009: by ResveratrolNews
The provision of high-dose resveratrol to laboratory mice not only cures many of them of metastatic (spreading) cancer, but produces complete immunity towards future cancer among surviving animals, even when tumor cells are intentionally re-injected into their bodies.
This astounding discovery has cancer researchers buzzing about a nutriceutical cancer vaccine that could revolutionize modern cancer therapy.
Researchers at the Department of Food Science, Chiayi University in Taiwan, injected laboratory mice twelve times with tumor cells which ended up in the lungs of the animals, mimicking metastatic colon cancer.
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August 29, 2009: by ResveratrolNews
Journal Comparative Physiology B (2008) 178:439–445
It may be difficult for humans to fathom that there is a African rodent that doesn’t age, is rarely ill, doesn’t get cancer, diabetes, or experience bone loss with advancing age, and whose females continuously produce babies and don’t experience a “change of life.” This tunneling rat outlives other rodents by ten fold. Your average pet lab rat lives ~3 years, this rodent 28-30 years!
Welcome to the world of the naked mole rat. Naked refers to its hairless pink skin.
Read the whole post »
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August 7, 2009: by ResveratrolNews
The Chicago Tribune report of a terminal cancer patient’s successful prolonged survival, credited to her use of a drug that inhibits the mTOR-gene pathway combined with “fresh-preserved” grapefruit juice, should have striking impact upon longevity seekers.
The reason? — The drug used to inhibit the mTOR gene pathway is rapamycin, recently heralded in the news media because it was found to significantly prolong (by 14%) the life of lab animals even though it was employed at a latter stage of their lifespan. [Nature. 2009 Jul 16;460(7253):392-5]
Rapamycin levels are so enhanced by grapefruit juice that once-weekly dosage produced drug concentrations equal to every-day dosing without juice.
Molecules in grapefruit juice are known to enhance the effects of drugs by inhibiting detoxification enzymes in the liver.
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August 4, 2009: by ResveratrolNews
Frank Weinberg and Navdeep S. Chandel, researchers at Northwestern University Medical School in Chicago, provide a profound new understanding of the role of reactive oxygen species in cases of cancer.
They report that tumor cells in lab dishes impair the production of p38, an inflammatory protein, and p53, an anti-cancer gene protein, to evade apoptosis (cell death) and for tumor generation to proceed.
In the diagram provided below these researchers distinguish reactive oxygen species (free radical generation) in normal cells vs tumor cells. In normal cells, low levels of oxygen free radicals can regulate controlled proliferation and growth via cell signaling whereas with high levels of free radicals induce cell death and senescence. Cancer cells with mutations in tumor suppressor genes (p53) can evade free radical generated cell death. Cancer cells exhibit high levels of free radicals leading to uncontrolled cellular proliferation (growth by rapid multiplication).
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August 2, 2009: by Bill Sardi
Researchers in France have conducted a striking experiment in animals to measure the chronobiological effects of resveratrol (rez-vair-ah-trawl), known as an antioxidant derived from red wine.
Chronobiology is a field of science that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar and lunar related rhythms. http://en.wikipedia.org/wiki/Chronobiology
Male rodents were administered resveratrol at three different dosages, equivalent to 56 mg, 140 mg and 350 mg, during light (day) and dark (night) periods and measurements of oxidation (TBARS- thiobarbituric acid reactive species) were conducted in heart, liver and kidney tissues.
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May 15, 2009: by ResveratrolNews
Vista, CA (May 13, 2009) – Roman soldiers wrapped their battle wounds in red wine and considered wine to be their best medicine. Over two-thousand years later, 88-year old Madeline May is just now catching on to what the Romans apparently knew centuries ago.
Madeline has been bed-ridden due to joint problems for many years now. With the aid of a walker she can barely hobble to the bathroom and back. Because of the pain, it takes about 5 minutes for her to stand erect. A trip to the bathroom and back is exhausting.
That was the “old” Madeline May. Today Madeline launches herself out of bed, is back in the kitchen washing dishes and doing house cleaning, and wants to take a trip to Montana to visit relatives. Madeline uses her walker now only out of habit. What brought about the sudden change?
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May 11, 2009: by ResveratrolNews
There are over 100 brands of resveratrol pills on the market, but only one is selling vigorously —ResV. And that is because of online fraud.
With the appearance of widespread interest in resveratrol in the aftermath of extolling report on CBS’ 60 Minutes, the Barbara Walters show and the Oprah show, budding entrepreneurs see an opportunity to add resveratrol to everything ranging from skin creams to bottled water. But the whole boom in resveratrol appears to be falsely created.
There was little public interest shown in resveratrol pills even after they were given glowing reports on CBS’ 60 Minutes, the Barbara Walters show and a go-ahead by Dr. Oz on the Oprah Winfrey TV show.
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