Comprehensive Library Of Resveratrol News

That question was recently asked at FightAging.org.

We already know the life expectancy of many Americans living in the same municipality differ widely.  A disturbing reality is that, for the first time since 1993, large decreases in life expectancy for some groups were noted.

According to a Stanford Institute For Economic Policy Research 2018 report, low- income Americans were living no longer than people living in 3^rd-world countries while high-income Americans were living longer than ever before.  The gap was wide with some groups only living into their 60s while others living to age 90 and beyond.  Even though some high-and-low income groups of Americans were living longer, there was almost a decade difference between groups.

Premature aging is not inevitable

While income and racial factors are involved, there is little or no genetic inevitability involved in premature aging nor is income a factor for longevity per se.

Environmental and nutritional factors were assessed in a recent report published in Nature Food.  This study revealed the consumption of one hot dog costs a person 36 minutes of “healthy” life.  While a serving of nuts and seeds produces a gain of 25 minutes of healthy life.  Consumption of processed meat was a lifespan shortening factor but should be qualified.  Is it the meat or the additives that produce this negative effect?  And given the fact meat is the primary source of absorbable heme iron needed to make red blood cells during childhood growth and during pregnancy for fertile women, meat should not be X’d off the list of longevity foods entirely.

This author postulates that aging is accelerated by the accumulation of iron, copper and calcium after full childhood growth is achieved in males (begins around age 18-20), and in females after menstrual blood losses cease (red blood cells carrying 80% of the iron load in the body).

Misdirected political conclusions

Misdirected political conclusions are made from this data that disparities in income or racial factors call for equality of income or at least a guaranteed minimum income.  That would not remedy the problem, as explained below.

Declining purchasing power and health

While the central Federal Reserve bank’s programmed inflation has been the driver over the past two decades in impoverishing Americans (a $35,000 income in 2000 would require a $55,635 income to have the same purchasing power today), combined with little or no gains in wealth among the bottom 90% of income earners over the past decade, has had significant impact upon health and longevity of many Americans. Regardless, high-income Americans making poor food choices and practicing poor health habits, particularly smoking, would end up shortening their lifespan.  In reverse, any low-income American could achieve exceptional longevity by adherence to a regimen of foods and health habits that hare not necessarily expensive.

Senescent cells = shorter life expectancy

What the FightAging.org report reveals is that aging is not due to unknown or un- measurable factors.  Smoking induces cell senescence, that is, living cells in the body that no longer have ability to renew themselves, resulting in a fragile state of health.  Smoking takes ten years off a person’s life.

This fragility can be observed in red blood cells themselves, and in chromosomes that house the library of genes in every living cell.  Increased cellular fragility is visible and is, for example, associated with bone fractures and impaired healing.

Inflammaging/ senescence

Senescent cells are inflamed cells.  Human aging has been called “inflammaging,” or chronic low-grade inflammation that commonly occurs but is not confined to old age.

The FightAging.org report focuses on diabetes and obesity as forms of accelerated aging.  Both diabetes and obesity are characterized by inflammation, and therefore by this definition, diabetes and obesity are forms of accelerated aging.

It is no surprise to learn that the anti-diabetic drug metformin is also considered as an anti-aging pill and an anti-senescent medication.

“How young can one die of old age?

The FightAging.org report asks: “How young can one die of old age? Our present societies of comfort and calories, with sizable populations of patients who are both obese and diabetic at ever younger ages, seem set on chasing an answer to that question.”

The FightAging.org report also indicates while humanity awaits controlled trials to prove this cell senescent theory of aging, “it is readily available to self-experimenters.”

Available today

No new synthetic molecules need be developed.  A protein kinase inhibiting drug, dasatinib, combined with quercetin, a natural molecule found in red apple peel and red onions, was found to kill 25-50% of senescent cells.  Natural molecules called polyphenols also inhibit protein kinase enzymes.  For example, fisetin, a strawberry molecule, has been found to abolish cell senescence.  Resveratrol, the red wine molecule, is a potent anti-senescent agent.  Combinations of these molecules exert synergistic rather than just additive benefits at lower doses.  The safety of these molecules suggests they can be used today to halt and even reverse cellular senescence and aging itself.

Many Americans await the OK from their doctors, or from government, before they embark on life-prolonging practices.

Why live old and die young?  While it is commonly said if a person lives long enough they will eventually develop cloudy cataracts.  But cell senescence is what drives cataract formation.  Even the inevitable maladies of old age may be delayed or avoided entirely.

Anti-senescent molecules have already been reported to delay or ward off chronic back aches.

Various tissues in the huma body age at different rates.  The fastest to age is human due to sun exposure.  Cell senescence is also what drives wrinkles in skin.  Who wouldn’t want to look younger in the mirror?

Cells become senescent at a rate of 10% per year

The rate of senescence is estimated to be 10% per year (probably after age 40).  The missing part of this story is modern medicine is nowhere part of this story, this understanding of how to reverse the curse of mankind – aging.  As human populations shrink in size (see the book EMPTY PLANET), we realize there is no real threat of over-population.  In developed countries women set the limit of children to ~2, which is population neutral.  The door is open for humans to live an indefinitely long and youthful life without crowding others living on the planet.

Experts claim the idea of keep cells young is worth a trillion dollars.  There is no cost for these anti-senescent molecules, only a price to pay if not electing to use them.