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How the world got lost on
the road to an anti-aging pill
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July 1, 2021: by Bill Sardi with Matthew Sardi
The news headline is discouraging to longevity seekers. Researchers recently said “We can’t cheat death!” — that the ageing process has not slowed down in humans- we’re just not dying younger. We are not adding years to the end of life.
After antibiotics, vaccines, organ transplants and modern medicines that only quell symptoms, anti-ageing researchers say there isn’t much that can be done to extend the human lifespan. Most of the added years of life have already been achieved. The variance we now observe in human lifespan has more to do with income and public hygiene than whether you eat Wheaties for breakfast or yogurt with dinner.
But that is an incomplete way of looking at human lifespan. The so-called “Invariant Rate Of Ageing” theory completely ignores the last 16 years of progress in our understanding of why humans age.
Humans don’t all march together to the grave. Even the researchers themselves say their “Invariant Rate Of Aging” hypothesis “does not rule out heterogeneity in the rate of aging among individuals within a population.”
We now know that our genes can be altered to molecularly mimic a calorie-restricted diet known to double the lifespan and healthspan of all living forms of life. An oversimplistic approach would be to tickle a survival gene and live one-hundred years and beyond.
| Invariant Rate of Ageing | Indefinitely Long Lifespan |
|---|---|
| Achieved by reduction of deaths at an earlier age with no change in lifespan variance | Achieved by adding years to the end of life via reduction of cell senescence via reduction or elimination of accumulated minerals |
| Variance is accomplished by public hygiene and reduction of infectious disease | Indefinitely long lifespan achieved by reduction in intake of minerals after childhood growth and/or removal of minerals |
| Archives ~around 18 years of additional life due to food quality, health habbits and hygiene | Achieved via reduced consumption of iron and calcium-foods |
| Homogenous Reduction in pre-adult mortality |
Room for Heterogeneity Individuals may achieve super longevity |
| Fewer people die before full growth is achieved (age 18) | Years are added to life after age 60 by slowing or even reversing the rate of ageing |
True, the oldest modern human being lived 122 years, but then researchers discovered that was achieved by deceit. Jean Calment of France was replaced by her daughter in order to avoid an inheritance tax. It doesn’t appear efforts to achieve super longevity will ever approach those of biblical patriarchs; or does it?
Here is what we know now.
If an antiaging pill were to be developed today it would activate the Sirtuin1 survival gene; it would inhibit the NFKappa B gene and slow or even reverse cell senescence (loss of ability of cells to renew themselves). It would also reduce low-grade inflammation which is the hallmark sign of ageing (called inflammaging). It would overcome even the worst diet and health habits. Such a pill exists today.
Is it really scientifically impossible to live in good health beyond 100 years? One wonders if negative reports like these are meant to discourage longevity seekers for political, social or economic reasons, rather than lack of scientific substantiation.
Despite thousands of scientific reports pointing to the fact it is now scientifically possible to prolong human life indefinitely, anti-aging pills are thrown under the rug. What is biologically possible is not politically or financially palatable. Anti-aging pills by definition would eliminate chronic age-related disease, the bread and butter of hospitals and drug companies.
It can be said that Americans are over-medicated; 24% take three of more prescription drugs; almost 13% take five or more Rx drugs. Almost 80% of doctor visits are for prescription drugs. Many people who take resveratrol pills today are otherwise free of medication.
This simply means people who opt to use so-called anti-aging pills have to make independent decisions to do so, outside the guidance of modern medicine.
Could a single molecule overcome the ravages of aging? The researcher who in 1997 initially reported on the promise of resveratrol to quell the many diseases of mankind says over 20,000 studies now confirm his initial studies – that resveratrol is a miracle molecule. His 1997 report said: “Implementation should commence immediately.” That was 23 years ago.
Out of 1000+ plant-based natural molecules, resveratrol stood out as the most promising pain reliever and anti-cancer agent. There is no natural or synthetic molecule that exerts such beneficial influence on the human genome (library of 25,000 genes) than any other molecule – what is called a “biological tsunami.” Yet it largely goes unused in today’s armamentarium of drugs. The 20,000+ research papers published about resveratrol have only served as obfuscation (to confuse, make things obscure).
The most common reason for taking prescription drugs is pain. Resveratrol is master pain reliever. But it goes unused even for that practical purpose.
Resveratrol is many drugs in one. And that is its most unbeguiling attribute. Resveratrol is not too good to be true, it is too true to be good.
Resveratrol is not too good to be true,
it is too true to be good.
Resveratrol threatens the income stream of the medical industry. Resveratrol could potentially bring down the entire $1 trillion pharmaceutical sector of the stock market.
Resveratrol posed such a threat to modern pharmacology that the $720-million sale and abrupt shut down of a developmental res-pill drug company was obviously intended to keep this molecule off the market.
Yet resveratrol is the only molecule whose molecular structure was fashioned into jewelry as if to say it is more valuable than gold!
Methinks life insurance companies and pension plans couldn’t possibly handle millions of American centenarians. Already, this year, the Social Security trust fund is insolvent due to a steep decline in tax collections from unemployed younger workers, a fact hidden from most Americans.
Resveratrol is a politically unsavory molecule. But a godsend for those who use it.
Researchers throw up the false claim that resveratrol couldn’t possibly be effective since it is so poorly absorbed that it doesn’t even enter the blood circulation in significant amounts. However, the often-stated claim that resveratrol is not readily absorbed has been found to be a “red herring,” (something misleading). While “there is no question regarding the absorption of resveratrol following oral consumption,” inexplicably scientific reports continue to say otherwise. Say that to the people who lost their vision and regained it by taking such a resveratrol pill.
Maybe resveratrol is too much of a good thing. If humans live longer only to outlast their retirement plan and over-populate the planet, maybe it SHOULD be kept in the closet. Maybe it would be better for mankind to die on time. But we find the idea of overpopulation is a myth.
The book EMPTY PLANET authoritatively documents human populations in developed countries are in decline. Western Europe, Italy, North America and Japan are shrinking populations. Even China now plans to loosen restrictions on the number of children per family. This represents a giant misdirection by population planners and biologists.
Don’t think the idea of starting a resveratrol pill company hasn’t crossed the minds of many. Over 500 start-up res-pill companies were once listed at the Comprehensive Natural Medicines Database.
For any junior biologists who would like to formulate their own anti-ageing pill, the first molecules they would select would be small, tiny enough to pass through cell walls and enter the genetic machinery of living cells. The pharmaceutical industry maintains many libraries of small molecules because of this. The objective of modern pharmacology is to alter these natural molecules into patentable synthetics and reap a whirlwind profit.
An anti-aging pill would have to be comprised of small molecules and make it past the blood-brain barrier. Examples are molecules called polyphenols such as resveratrol (grapes, wine), quercetin (red apple peel) and fisetin (strawberries).
Each of these molecules happens to chelate (attach to) minerals which accumulate over time in the human body. It is the accumulation of minerals with advancing years that controls the rate of ageing. The Overmineralization Theory of Aging was initially proposed in 2007 by this author and has not been dismissed.
It is no coincidence that the Japanese who live in a country with very little grassland to feed cattle, and therefore consume very little iron-rich beef and calcium-rich dairy, live the longest on the planet.
Incredulously, nearly 1 in 1500 people in Japan are now age 100 or older.
Superlongevity has been achieved in Japan in a short time span. In 1963, when Japan first recorded the country’s centenarian population, there were just 153 people 100 years and over in the country. Five decades later, in 2015, there were 61,568 people that old (2015), according to the Japanese Ministry of Labor, Health and Welfare.
That is 0.048 percent of the population, according to the U.N.’s Revision of World Population Prospects 2015 estimates, making Japan the country with the most centenarians per capita in the world. The United States has more centenarians, 71,972, but that figure represents only 0.022 percent of the population.
Now, if you can even believe this, the Japanese centenarian population exceeds 70,000 (2018).
What the Japanese are unintentionally experiencing as a society with diet is what American longevity seekers are intentionally experiencing with an anti-ageing pill.
None dare put res pills to a fair test. The only conclusive evidence for an anti-aging pill would be a long-term (50-year) controlled trial compared with an inactive placebo. That would be impractical. So we have to settle for markers of aging, namely, gene expression (protein making).
When in 2008 anti-ageing researchers used multiple polyphenols in laboratory mice for 12-weeks, they discovered this combination activated 9 times more longevity genes than the red wine molecule resveratrol alone. Many users of this formula (Longevinex®) have been taking it for over decade and have experienced unusual vitality and health compared to their age-matched peers.
Recently a Longevinex® user had his biological age tested. He discovered his biological age was 20 years younger than his chronological (calendar) age. He is in his late 80’s now.
There is little question an anti-ageing pill would put modern medicine out of business. But ironically, insurance trust funds are empty without such a pill. With so many millions of Americans out of work, and no contributions being taken as payroll deductions for future Medicare, the door is now open for an anti-ageing pill that would dramatically reduce healthcare costs.
Coincidently, resveratrol blocks every pathway of coronavirus pathology. An anti-ageing pill not only serves to prolong human life but also to save it.
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