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How the world got lost on
the road to an anti-aging pill
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October 25, 2021: by Bill Sardi
The story is all too familiar. Researchers say they have developed some synthetic molecule that will cure a disease like diabetes, eradicate cancer, prevent blindness, and to wait another decade or two while it is developed. The molecule is patented. It developers dream of the day they become billionaires. But most affected patients won’t be alive for that day.
A recent screening involving 1,596 compounds related to protein degradation led to the discovery of a synthetic molecule called CPD1. This molecule suppressed the development of breast, lung and colon cancers in lab animals and improves survival rates. A startup company has been formed to carry this new drug through trials as a hopeful cure for cancer. Millions of dollars of capital are being invested.
The target of this drug is the SUMO gene, which when activated promotes cancer. The SUMO gene makes SUMO enzymes (proteins), in a process called epigenetics.
Up until 2018 no small molecule had been designed to effectively inhibit the SUMO enzyme. Most SUMO inhibitors display weak anticancer activity.
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September 21, 2021: by Bill Sardi
The utility of the red wine molecule resveratrol is gaining traction every day.
Who would have guessed?
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August 18, 2021: by Bill Sardi
Life extension (longevity) is one thing. Health extension is another.
Society values both. What the public dreads is one without the other, living longer in misery. The 30-year rise in life expectancy in the last 120 years is one of humanity’s greatest achievements (healthy life expectancy at birth is now ~78.9 and 68.5 years, females/males). But prolonged lifespan hasn’t been accompanied by extended healthspan.
Longevity has been achieved in a costly way, by over-drugging and treating each and every chronic age-related disease separately by a bevy of medical specialists. Modern medicines do a reasonably good job of lowering numbers (cholesterol, PSA, blood sugar, blood pressure) but fails to address the main cause of chronic diseases – aging. Human lifespan has been expanded beyond healthspan, which means people suffer through the last decades of their lives in a chronic debilitated state.
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August 6, 2021: by Bill Sardi
Why are older Americans more likely to succumb to infections such as the COVID-19 coronavirus?
One answer to that question resides in the fact older adults have more non-renewable senescent cells in their bodies when renders them more vulnerable to disease. They also have fewer and more sluggish natural killer cells, a type of white blood cell known for directly eradicating cancer cells. NK cells do this by secretion of interferon and tumor necrosis (death) factor (TNF)s.
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July 26, 2021: by Bill Sardi
Depending upon which source of information you believe, your life is in the balance if you make the wrong decision about COVID-19 vaccination.
A problem with what I write today is that the information below, which is essential to know to maintain health following COVID-19 vaccination, may induce more fear and anxiety, which is what is driving the pandemic and the misdirected decisions over COVID-19 vaccination. I’ll explain more about this below.
According to Our World Data as of July 20, 2021, 161 million Americans are fully vaccinated out of a population of ~328 million (49.1%).
It is difficult to understand why anyone would immunize, not with a vaccine, but a 5-times gain-of-function bioweapon, which is what the COVID-19 RNA/DNA vaccines are. But the news media is running a fright campaign that causes people to make health decisions out of fear.
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July 14, 2021: by Bill Sardi
105-Year-Old Man In Italy Discovered With An Immune System Of A 25-Year Old
CXCL9 Protein In Blood Determines “How Far Along A Person Is In Their Inexorable March To The Grave.”
Red Wine Molecule May Produce Biologically Young Centenarians
Researchers at Stanford University and the Buck Institute announce the remarkable discovery of a biological clock in human blood that can determine your “inflammatory age” (iAge) which equates with longevity. iAge can now be used to track risk to develop chronic age-related frailty. Anticipate blood test kits to be available soon.
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July 13, 2021: by Bill Sardi with Matthew Sardi
The average length of service for enlisted personnel in the US military is just under 15 years. The average age of enlistment in the US army is ~ age 21 and the average age of US army enlisted men and women is ~age 27. Only ~9% of army personnel are over age 40. These troops have barely begun to age biologically. So, what’s the impetus to introduce an anti-aging pill in today’s military?
The US Military’s Special Operations Command (SOCOM) intends to test an experimental pill as “smart weaponry” to enhance performance in the battlefield. News headlines portray this as a nutraceutical that will stave off the effects of ageing on older soldiers.
“It has the capacity, if successful, to actually prevent ageing and hasten recovery from injury as well as enhance mental function,” say news reports.
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July 11, 2021: by Bill Sardi
Most people have the results of a prior blood test that shows numbers for total cholesterol, good (HDL) and bad (LDL) cholesterol, and triglycerides. Sometimes the blood test includes lipoprotein(a), that has been called a “mysterious factor” in heart disease. Lipoprotein(a) is perplexing to both doctors and patients alike.
Patients with elevated lipoprotein(a) levels, which is a fatty protein produced in the liver that enters the blood circulation and increases risk for a heart attack, primarily affects 1 in 250 individuals worldwide with a family history. About 60 million Americans have elevated Lp(a) levels. Roughly 1 in 7 heart attacks are associated with high Lp(a) levels. Concentrations of Lp(a) vary by 1000-fold between individuals.
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July 8, 2021: by Bill Sardi
The validity of medical reports in medical journals has recently been challenged, particularly in this era of fake news and COVID-19 scaremongering, as evidenced by the unprecedented retraction of reports published in two major elite medical journals about the coronavirus pandemic.
Turns out, after an America’s Frontline Doctors citizens’ petition, just 152 of 17,000 deaths attributed to COVID-19 in Lisbon, Portugal were confirmed (0.9%)! The polymerase chain reaction (PCR) test used to confirm COVID-19 was set at sensitivity of 35 instead of 18, which resulted in 97% of these tests being false positive. A person may have died, and they may have had a positive PCR COVID-19 test, but they didn’t die of COVID-19 because the test was intentionally flawed.
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July 1, 2021: by Bill Sardi with Matthew Sardi
The news headline is discouraging to longevity seekers. Researchers recently said “We can’t cheat death!” — that the ageing process has not slowed down in humans- we’re just not dying younger. We are not adding years to the end of life.
After antibiotics, vaccines, organ transplants and modern medicines that only quell symptoms, anti-ageing researchers say there isn’t much that can be done to extend the human lifespan. Most of the added years of life have already been achieved. The variance we now observe in human lifespan has more to do with income and public hygiene than whether you eat Wheaties for breakfast or yogurt with dinner.
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