Comprehensive Library Of Resveratrol News

MIT researchers made news headlines over a discovery that could help people not only live longer but retain their memory and other mental capacities throughout life.

There are three ways to control genes: 1) by activation or inactivation of proteins, called gene expression or silencing; 2) alteration of microRNA; or 3) by tightening or loosening DNA strands around spools called histone bodies.  Histone bodies are comprised of lysine and arginine.  Think of a DNA strand like a cord wrapped around a tennis ball (histone body).  When strands of DNA are bound loosely around histone bodies, the DNA sequences can be “read” and activated.  When DNA strands are tightened around histone bodies, the genes are shut off.

The enzyme histone deacetylase (HDAC1) was found to produce potential health and longevity benefits.

HDAC1 also slows the cell renewal cycle, allowing more time for DNA to be repaired.

Laboratory mice that had HDAC experimentally “knocked-out” displayed longer times to navigate a water maze, a direct measure of mental capacity.

MIT researchers used a synthetic drug molecule to activate DNA via HDAC1, but the red wine molecule would suffice as a substitute in this experiment.

Histone deacetylase enzymes loosen DNA binding around histone bodies and activate the SIRTUIN1 survival gene, the same gene that is activated during fasting (calorie restriction) and molecules that mimic calorie restriction, resveratrol being most powerful.

In other words, since resveratrol is commercially available to the public, humans can take measures to include supplemental levels of resveratrol in their daily health regimens and begin experiencing proposed health benefits immediately rather than waiting for drugs to be approved for specific maladies years from now.  Resveratrol via its activation of HDACs and the SIRTUIN1 survival gene controls many genes and therefore, delays or blocks the onset of many age-related disorders.

In a prior test, resveratrol demonstrably retained activity (via a process called methylation) of three different genes.

Resveratrol plus quercetin, two natural molecules, appear to work in a superior fashion to limit DNA damage.

For further information: LONGEVINEX.com