Comprehensive Library Of Resveratrol News

Resveratrol is a natural compound found in grape seeds, peels and red wine. Resveratrol inhibits infections caused by multiple pathogens and shows inhibiting effects in a variety of human viruses, including influenza virus, herpes simplex virus, respiratory syncytial virus, HIV-1, varicella-zoster virus, enterovirus-71, human meta-pneumovirus, human rhinovirus-16, polyoma virus and cytomegalovirus.

Resveratrol has antiviral activity against respiratory viruses and certain anti-inflammatory effects, so it can be used as an adjuvant treatment for respiratory infections.

Resveratrol has a wide range of antiviral effects by down-regulating inflammatory signal transduction, which is mainly associated with the inhibition of viral replication, viral protein synthesis, gene expression, and nucleic acid synthesis.

In vitro model evaluations show that resveratrol significantly inhibits MERS-CoV virus infection in a dose-dependent manner and prolongs the survival time of infected cells, which may be related to resveratrol’s reduction of nucleocapsid (N) protein expression. Nucleocapsid (N) protein is a multifunctional protein essential for CoVid replication.

In addition, resveratrol down-regulates MERS-CoVid-induced apoptosis in vitro. In the case of continuous administration, resveratrol can inhibit MERS-CoVid at lower doses. Another study shows that resveratrol also has a significant inhibitory effect on the emerging positive sense RNA Chikungunya virus, indicating that resveratrol may become a candidate drug for the treatment of new RNA viruses.

Source: International Journal Medical Sciences Volume 17, 2020. https://www.medsci.org/v17p1803.htm