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How the world got lost on
the road to an anti-aging pill
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December 26, 2018: by Bill Sardi
Photo: Corey Kilgannon
Before I get to the incredible story of Anthony Mancinelli, age 107, there is also the story of Joao Coelho de Souza, born March 10, 1884 (there isn’t supposed to be anybody alive that was born in the 1800s) who has records to prove he was 131 years old in 2016. Is the Coelho de Souza report valid?
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December 13, 2018: by Bill Sardi
CLINICIAN’S GUIDE TO RESVERATROL DISPELS INACCURACIES AND MYTHS ABOUT RESVERATROL
FOR HEALTH PROFESSIONALS
This report pertains to:
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December 10, 2018: by Bill Sardi
In the anti-aging pill arena 2018 has been the year of senolytic drugs – the prospect that synthetic molecules could soon erase the ravages of aging produced by a progressive aging process called cell senescence.
Four major milestones have been achieved in rapid fashion.These four developments started in 2011 with an animal study where the destruction of “senescent” cells improved the lifespan and health span of laboratory mice.That was followed by (2) the identification of small natural molecules that are capable of clearing the body of “senescent” cells; then (3) these molecules were then shown to improve the lifespan and function of aged mice; and (4) pre-clinical studies show these molecules are successful in quelling a wide range of maladies.
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November 8, 2018: by Bill Sardi
Some 14 years ago I ventured to Harvard Medical School to interview Harvard Professor David Sinclair, who became the pied piper of anti-aging pills with his published discoveries involving the red wine molecule resveratrol. I ended up writing a book THE ANTI-AGING PILL (now a rare book at Amazon) and was confronted by an unexpected fact: most people don’t want to achieve super-longevity. They would rather retain a youthful appearance over living long enough to drool at the mouth, need to wear diapers to handle their incontinence and be drugged into mindlessness. This is what modern medicine has made of old, old age. As someone once said to me: “What people want is thick hair, smooth skin and Viagra baby!” I ended up re-titling my book to THE RED WINE PILL, which was more appealing.
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October 30, 2018: by Bill Sardi
While the cancer research community is furiously working to develop synthetic micro-RNAs that will selectively kill cancer cells, the red wine molecule resveratrol appears to naturally activate a cancer kill switch that is being heralded today as an alternative to toxic chemotherapy.
Scientists now say they have found a sequence of three nucleotides (steps on the RNA ladder) that kill cancer cells by virtue of their ability to eliminate three survival genes. The proposed treatment is called DISE (Death Induced by Survival Gene Elimination).
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October 22, 2018: by Bill Sardi
Over 7 million results for “resveratrol” on the Google search engine. Sixty years of research; 133 human clinical trials; twenty thousand (20,000) published research papers plus symposia, conferences, patents and attempts to produce analog drugs (synthetic resveratrol-like molecules). Doses ranging from 5-5000-milligrams have been put to the test in humans. This is what a recent landmark retrospective report reveals (Biomolecules & Therapeutics, Oct. 2018). But that portrayal of resveratrol needs to be re-written not only to correct misinformation but to reveal valid science that modern medicine has never dared to put into practice.
The author of that report is a leading researcher whose groundbreaking research opened the door to study resveratrol. His worldwide investigation on behalf of the American Cancer Society concluded that among all of the thousands of natural molecules studied, resveratrol deserved singular attention because it halted cancer at all three stages of development – initiation, growth and metastasis (spread), something no existing cancer drug can say some two decades later. The author, Professor John M. Pezzuto PhD, has written 38 published papers about resveratrol since 1997 and has applied for a number of patents as well.
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August 15, 2018: by Bill Sardi
Longevity seekers, don’t be fooled by news headlines that now talk about reversing aging in living cells with synthetically created molecules.
Anti-aging researchers are lauding themselves for reversing aging in living cells. One researcher said: “When I saw some of the cells in the culture dish rejuvenating I couldn’t believe it. The old cells were looking like young cells. It was like magic.” (Readers can now offer applause.)
Researchers are talking about restoration of something called splicing factors that facilitate the prolongation of telomeres, those end caps on chromosomes and delay or even reverse cells from becoming senescent – the cells stop dividing and replicating. Synthetic compounds were reportedly used to reduce cell senescence by up to 50%.
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July 25, 2018: by Bill Sardi
Well, it took 14 years for the research community to conduct a simple human study to determine if resveratrol raises Sirtuin1 gene protein blood levels as well as a calorie restricted diet. The study was conducted among healthy or slightly overweight subjects. Since blood measures of cholesterol, insulin and blood sugar were already within the healthy range in these subjects, neither a limited calorie diet nor resveratrol had any significant effects upon these measures, nor upon heart rate, weight, waist circumference or blood pressure.
Read the whole post »
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July 11, 2018: by Bill Sardi
A news report is making resveratrol pill users wonder whether they are using the best form of this molecule for their health. Scientific debate continues over whether a form of resveratrol that is advertised to be more bioavailable (pterostilbene) is superior to plain resveratrol.
As background information, resveratrol is a molecule that human body perceives as a toxin and seeks to detoxify it as it passes through the liver. Resveratrol is an antioxidant when given in modest doses (100-350 mg) but promotes oxidation when given in mega-doses (2800 mg).
For example, a human equivalent dose of 2800 mg was shown to increase the size of a heart attack (area of damaged heart muscle) whereas a modest dose decreases the area of damage. In fact, 2800 mg resveratrol actually “kills” a pumping rodent heart. However, when resveratrol is complexed with quercetin and rice bran IP6 (Longevinex®) there is no cardiac toxicity whatsoever (see chart below), making Longevinex® the safest resveratrol pill available should mega-doses be mistakenly consumed.
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June 29, 2018: by Bill Sardi
As I write on this 4th of July 2018 so many questions flood my mind regarding human longevity. Where is humanity headed? One unquestionable direction is, despite the vast majority of humans on the planet live in poverty and suffer from malnutrition, is that people are reported to be living far longer in developed countries. How much longer? Well, maybe just ten years.
Life expectancy is not an accurate measure of longevity because it is skewed downward by infant mortality. What is instructive is global life expectancy at age 60, which is tabulated at Global Watch Index.
Data tabulated for 2015 shows in a number of advanced countries, people at age 60 are likely to live another 25 years or so (tops is Japan at 26 years; US 23 years) whereas in undeveloped lands, people reaching age 60 are likely to live another 15 years. So the net lifespan gain accomplished by access and delivery of modern medicines, antibiotics, etc. is about 10 years when population groups are compared.
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