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How the world got lost on
the road to an anti-aging pill
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June 23, 2014: by Bill Sardi
It may come as a surprise to learn that a key and irreplaceable layer of cells in the human retina called retinal pigment epithelium are “immune cells.” That is, they are phagocytes – cells that protect the light-sensitive retina by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells.
Every morning, upon stimulation by light, the human retina sheds used-up vitamin A in a self-renewal process. If the used-up vitamin A is not disposed of properly, cellular debris will accumulate and eventually destroy photo (light) receptor cells. This process describes a serious eye problem called night blindness (retinitis pigmentosa). The red wine molecule resveratrol activates phagocytosis and proper disposal of cellular debris.
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May 28, 2014: by Bill Sardi
Over a decade ago the public chose biodegradable plastic, a driverless car and a fully automated home over an anti-aging pill as the most desired inventions. [MIT survey 1997] Today we have driverless cars, semi-automated homes, smart eyeglasses, and humanity is just a step shy of having Dick Tracy wrist radios. So what technologies does the public now want technology to develop?
Philips UK [Philips.co.uk], largely known as a leader in lighting but promotes itself as an innovation company, conducted a survey of 1000 adults in Britain and reports that two-thirds of Britons hope for a cure-all pill over other possible inventions technology can deliver over the next 100 years. [Daily Mail UK May 27, 2014]
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May 25, 2014: by Bill Sardi
What you won’t hear about stem cell technology is that it is a flop. Despite billions of dollars of investment money, it is going nowhere. In fact, what is going on today in research labs doesn’t even involve stem cells. You can read more about it at Dr. William Prather’s article entitled “The Unrealized Potential Of Stem Cell Therapy.” [DDD Magazine Oct 2013]
A problem with the stem cell industry is that it becomes so difficult to scuttle a research program that employs so many people at a time when unemployment is a national embarrassment. There are an estimated 6100 full-time employees working in regenerative medicine and over 100 companies involved in stem cell therapies. There were 537 patents filed for stem cell technology in 2007. The National Institutes of Health is reported to have spent $546 million on embryonic stem cell research. [StemCellAction.org] This perpetually promising industry is only in operation as long as it is government subsidized.
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May 16, 2014: by Bill Sardi
You can read them all — all 279 of them at GoogleNews. Modern medicine can release falsehoods against one of the most promising dietary supplement ingredients and the news media will propagate it without question.
It’s obvious the nation’s health reporters mindlessly parroted the press release emanating from Johns Hopkins Medicine that errantly claimed the red wine molecule resveratrol (rez-vair-ah-trol) was of worthless value in reducing overall mortality among senior adults living in a wine-making region of Italy over a period of 9 years. Over 279 news reporters never doubted what researchers said. They just re-wrote the news story and hurried it into publication.
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May 15, 2014: by Bill Sardi
A man was overheard while standing in the checkout line at a Trader Joe’s market with a bottle of wine in his hand wondering out loud if wine drinking was worth it any more after hearing a recent news report saying the latest long-term (9-year) study showed wine drinking did not lower overall mortality rates among senior adults living in a wine-growing region in Italy. Ah, would even the Italians back away from their traditional wine drinking?
What they should be backing away from is tobacco. My linked report explains the whole mess and reveals how modern medicine is fabricating false information about dietary supplements to no end. [Has The So-Called French Paradox Vanished, Or Just Obscured By A Tobacco Smoke Screen? ] Examine the science for yourself.
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: by Bill Sardi
A gene protein called KLOTHO is being hailed as the new fountain of youth today. KLOTHO gene protein boosts brain skills (thinking, learning, memory), elevating IQ by six points regardless of the age of the person.
According to the news report [Daily Mail UK, May 11, 2014], among 700 subjects age 52-85 years of age, those with an inherited form of the KLOTHO gene called KLOTHO-VS performed better on mental tests. There is less KLOTHO gene protein in the aged brain. [Future Medicinal Chemistry, Sept 2012]
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: by Bill Sardi
A recently published study claims to reverse decades of research studies which invariably show moderate wine drinking (3-5 glasses/day) results in a dramatic decline in coronary artery disease mortality. Does this recent study erase the so-called French Paradox where the wine drinking French in the 1990s were reported to have a far lower rate of mortality from coronary artery disease (90 per 100,000) than North Americans (240 per 100,000 at the time)? [British Medical Journal May 6, 1995]
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May 12, 2014: by Bill Sardi
News headlines are screaming today that resveratrol (rez-vair-ah-trol) as obtained from red wine did not reduce mortality rates among adults living in the Tuscany region of Italy. [JAMA Internal Medicine May 12, 2014] But the news headlines failed to mention that modest red wine intake nearly halved the percentage of adults who were considered cognitively impaired as measured by a mental test.
The percentage of adults who were judged to be mentally impaired was 32.8% in the teetotaler low-wine/resveratrol drinking group versus just 16.4% among the high-wine/resveratrol drinking group (~2.6 glasses of wine/day). Authors of the study only devoted one sentence to this dramatic finding.
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May 5, 2014: by Bill Sardi
Added to the growing body of bad resveratrol science, researchers in China put resveratrol to the test in laboratory dishes. They test red wine and red wine with 10-fold more added resveratrol and mistakenly conclude that resveratrol offered less antioxidant activity than red wine. The investigators conclude that: “resveratrol may offer negligible health benefits compared to red wine (paraphrased).” [Food Chemistry Aug 1, 2014]
Fact: resveratrol is not a strong antioxidant. It works by provoking a mild biological stress, mimicking food deprivation, which in turn activates a gene switch (Nrf2) that triggers the production of internal enzymatic antioxidants (catalase, glutathione and superoxide dismutase). [Current Molecular Medicine Dec. 2011]
These researchers certainly must know of the so-called hormesis effect where a mild biological stressor provokes a major protective response in the human body via the Nrf2 gene transcription factor. The call must be out in the research communicity to disparage resveratrol. It is all part of a hidden agenda to warn the public away from resveratrol in dietary supplements and advise them to wait for a resveratrol-like drug. ©2014 Bill Sardi, ResveratrolNews.com
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: by Bill Sardi
Colin Selman
Institute of Biodiversity
College of Medicine
University of Glasgow UK Colin.Selman@glasgow.ac.uk
From: Bill Sardi, Knowledge of Health, Inc. and Resveratrol Partners LLC, USA
Having read your recent published paper on the pursuit of effective calorie restriction mimics published in Proceedings of The Nutrition Society (volume 73, page 260-70, 2014; abstract below) and ten years of observing the field of anti-aging research, I can say that the reality of what is going on in the profession is far from what your paper depicts.
I’m sorry if it sounds like I’m lecturing you here, but I have a theory of aging I want to share.
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