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How the world got lost on
the road to an anti-aging pill
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May 5, 2014: by Bill Sardi
Recently reported science suggests the idea of infusing young blood from grandchildren into their grandparents’ circulatory system would invigorate their memory and learning. Nobody has suggested this be done yet in humans. The experiments have been confined to laboratory animals. But a review of the medical literature suggests there may be an easier way to do this using a red wine resveratrol pill.
The recently reported science isn’t new but it is exciting. Joining laboratory mice in old/young pairs by stitching their skin together with adjoined blood vessels has been demonstrated to renew the brains of older mice, proving that blood factors can produce younger functioning brains.
The experiment was performed by researchers at the University of California San Francisco (UCSF) [Nature Medicine May 4, 2014] and is a follow-up study to earlier experiments published in 2011 [Nature August 31, 2011] and initially reported in 1960 by noted aging researcher Clive McCay. [Gerontologia 1960]
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April 30, 2014: by Bill Sardi
Scripps Research Institute researchers extol the red wine molecule resveratrol (rez-vair-ah-trol) in a recently published report [ELIFE, April 24, 2014] that caught the eye of a news reporter with the Palm Beach Post in Florida. [Palm Beach Post, April 29, 2014]
But somehow the promising research in lab dishes and the animal lab has not been demonstrated in humans, so these researchers say. This biological inconsistency occurs because researchers over-dose lab animals and humans, knowing full well that resveratrol turns from an antioxidant to promote oxidation in high-dose concentration.
For example, in one animal study the human equivalent of 28,000 milligrams (400 mg per kilogram of body weight) in a 160-pound human was used with negative results [PLoS One, Jan. 8, 2014] in animal eyes when low-dose resveratrol had already been demonstrated to be beneficial in human eyes. [Nutrients June 4, 2013]
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April 22, 2014: by Bill Sardi
Source: Nutrients 2013, 5(6), 1989-2005
Swelling and abnormal new blood vessel growth dramatically better with improved visual acuity, less visual distortion and improved visual acuity (from 20/70 to 20/50) within 7 weeks.
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April 16, 2014: by Bill Sardi
At the first international resveratrol conference in Denmark (Resveratrol 2010) the working group stated that the evidence was “not sufficiently strong to justify recommendation for the chronic administration of resveratrol to human beings, beyond the dose which can be obtained from dietary sources.” [Annals N Y Academy Science 2013 Jul; 1290:1-11]
An often heard issue is the lack of bioavailability of resveratrol. This is caused by the attachment of detoxification molecules (sulfate, glucuronate) to resveratrol as it passes through the liver.
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April 10, 2014: by Bill Sardi
Typically diabetics exhibit high circulating insulin levels and lack of sensitivity to insulin. The prospect of successfully employing resveratrol to treat diabetes is an ongoing quest that has been muddied by scientific studies that appear to have been designed to fail.
Recently researchers in Asia sorted out all the published studies involving resveratrol and diabetes and found that resveratrol remarkably controls blood sugar and insulin in diabetic individuals but has no effect among healthy individuals. [American Journal Clinical Nutrition, April 2014] That means resveratrol is an ideal blood sugar control agent as it doesn’t induce hypoglycemia (low blood sugar) when taken by healthy subjects.
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April 7, 2014: by Bill Sardi
A Harvard Medical School geneticist is known as the pied piper of anti-aging pills. His latest speech delivered at the University of Nebraska Medical Center is captured in printed text and a 16-minute video by the Nebraska World-Herald, and can be accessed online here.
This boyish-faced Harvard prof first made a connection between a survival gene (Sirtuin1) and life-prolonging limited calorie diets and a red wine molecule (resveratrol) that activates the same gene in a NATURE journal report published in 2003.
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March 31, 2014: by Bill Sardi
Longevinex® Achieves Age Reversal Effect Via Alternate Gene Pathway
Late last year when biologists announced in the journal CELL that a niacin-like molecule restores energy to aged cells, reversing markers of aging akin to making a 60-year old human 20-years old again, the mechanism described was attention getting.
Slowing the rate of aging desirable, though such an accomplishment has limited utility among those who have already lived most of their lives. The idea of a pill that can not only slow but also reverse aging has captured the attention of noted inventor and futurist Ray Kurzweil. This discovery means it is never too late in life to address aging with anti-aging strategies.
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February 8, 2014: by Bill Sardi
Back in July of 2013 this writer rebutted a published report in The Journal of Physiology that resveratrol reversed the beneficial effects of exercise among healthy aged males. I wasn’t the only party who objected to the false conclusions made by researchers at the University of Copenhagen.
I noted that at no time did any of the measured numbers, cholesterol, blood pressure or blood sugar, fall outside the optimal range in the group that took resveratrol, though they were marginally different from males given a placebo pill. The conclusions drawn from this study, and the widespread news headlines that followed, were are giant misdirection.
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January 5, 2014: by Bill Sardi
“Old age is the harbor
of all ills.” –Bion
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January 3, 2014: by Bill Sardi
Recently researchers said they were able to reverse biological aging for the first time using a derivative of vitamin B3 niacin.
A report in the journal CELL noted that the use of a derivative of vitamin B3/niacin called nicotinamide stimulates the production of nicotinamide adenine dinucleotide (NAD), a key protein in cellular metabolism (use of sugar for cellular energy) and cellular respiration (use of oxygen for cellular energy) in the mitochondria of cells.
There are a few hundred mitochondria in living cells. Mitochondria are atomic power plants that produce cell energy in the form of adenotriphosphate (ATP). By molecularly promoting more NAD/ATP in the mitochondria researchers were able to demonstrate that aging largely occurs in the mitochondria rather than the nucleus of cells and that production of NAD was able to reverse aging in muscle tissue of a laboratory mouse equivalent to making a 60-year old human 20-years old again!
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