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How the world got lost on
the road to an anti-aging pill
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December 24, 2013: by Bill Sardi
When a Harvard biologist announced biological aging had been reversed in just one week by the use of a compound that invigorates energy-producing compartments called mitochondria inside living cells, the news was spread worldwide. But the bottom line lesson from this landmark study was to wait a few years for Big Pharma to develop an expensive prescription drug to duplicate this unprecedented experiment.
And indeed, the results of the experiment were extraordinary – the muscle tissue in an aged (22-month old) laboratory mouse reverted back to a more youthful state in just one week, equivalent to turning a 60-year old human back to being 20 again! (A technical abstract of the report is published at the journal CELL.) Now if we could only erase those wrinkles!
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December 20, 2013: by Bill Sardi
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November 8, 2013: by Bill Sardi
In 2003 when a Harvard professor first heralded resveratrol (rezvair-ah-trol) as the key molecule in red wine that was both responsible for the French Paradox (the fact the wine-drinking French experienced a far lower rate of mortality from coronary artery disease than North Americans) and it also molecularly mimics a calorie-restricted diet, one would have bet it would be an up and coming dietary supplement or maybe even an FDA-approved drug. It had been touted as the only molecule found to block the development of all three stages of cancer (initiation, growth and spread) in 1997.
But ten years later, after researchers repeatedly (and falsely) claimed resveratrol is not biologically available, and after it was intentionally overdosed animals and even humans to produce negative studies, and a leading researcher was falsely accused of scientific fraud, sales of this promising natural molecule are in steep decline. Three years ago sales of resveratrol supplements were estimated at $30,000,000 and have now dropped below $18,000,000.
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October 24, 2013: by Bill Sardi
Virologists, reporting in Nature Medicine, are searching for a way to make a universal flu vaccine that would address fast-mutating flu viruses that vaccines cannot possibly develop antibodies towards. Surface proteins on flu viruses mutate so rapidly that block flu vaccines from addressing the exact flu strain in circulation.
Researchers have discovered that volunteers who develop flu symptoms and experience only mild symptoms have more of a particular type of white blood cell – identified as CD8-T cells. (T-cells are generated from the thymus gland.) CD8-T cells target the core of the flu virus rather than the surface proteins the conventional vaccines address. A CD8-T cell activating vaccine is in the making, say researchers.
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October 11, 2013: by Bill Sardi
It’s being called a “turning point in the history of Alzheimer’s disease” as scientists report they have halted the death of brain cells in laboratory mice.
Investigators say this discovery may “raise the possibility of new drugs to treat brain conditions like Parkinson’s disease as well as Alzheimer’s.”
These researchers describe their work “as the first real evidence it is possible to use a drug to stop diseased brain cells from dying.”
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October 4, 2013: by Bill Sardi
After a decade of scientific doubt that resveratrol is biologically available in the human body following liver metabolism, cancer researchers in Great Britain demonstrate that not only does the red wine molecule resveratrol exert biological action but liver metabolism potentiates it.
Mistakenly believing resveratrol is not biologically available once it attaches to detoxification molecules (sulfate, glucuronate) as it passes through the liver, in 2010 mega-dose (5000 mg) resveratrol was employed in a human study of bone marrow (multiple myeloma) patients which resulted in immediate kidney failure that put a halt to the trial.
Also a human clinical trial has been launched employing mega-dose resveratrol among Alzheimer’s subjects, with dosing being established by the assumption resveratrol is not bioavailable.
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September 25, 2013: by Bill Sardi
The poverty in India has led to the common practice that Hippocrates embraced: “Let food be thy medicine and medicine thy food.” Many East Indian medical researchers fondly embrace this idea as it is a customary part of the gastronomy of this still impoverished country.
Having visited there twice to attend recent scientific research symposiums, first in Chennai (the old Madras) and then Kolkata (the old Calcutta), it is clearly evident that spices added to many East Indian dishes serve as medicine. Many households there cannot afford western medicines. Aspirin, as cheap as it may seem, is not popular there. The herb holy basil serves as the aspirin of India.
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September 20, 2013: by Bill Sardi
Marketing a resveratrol-based dietary supplement has given me a front-row seat to view how modern medicine obfuscates science and throws in other roadblocks to indefinitely delay public acceptance of a truly miraculous natural molecule.
Examination of events and published studies involving the red wine molecule resveratrol (rez-vair-a-trol) over the past decade reveals nine ways modern medicine has attempted to muddy the science and delay public adoption of this natural molecule as an affordable dietary supplement.
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September 19, 2013: by Bill Sardi
There is one technology challenge that is still beyond the reach of wealthy elite humans — avoidance of death.
Dare they chase the wind in an attempt to capture immortality?
That is what Google co-founder and CEO Larry Page now sets his sights on – an anti-aging pill. However, there are a lot of obstacles intentionally being thrown in the way.
Google’s objective is not new, nor is it far-fetched.
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September 6, 2013: by Bill Sardi
If it is a patentable synthetic molecule that could make research institutions and pharmaceutical companies billions of dollars, it will surely be heralded. But if it is an un-patentable natural molecule that does the same thing at far less cost, it will predictably be dismissed.
That is the current state of affairs when it comes to technology that would limit damage caused by a heart attack.
Researchers at Yale University report their MIF20 small molecule reduced damage to heart muscle by ~40% in an experimental animal model. The Yale researchers report their findings here.
These Yale researchers “Suggest that augmentation of endogenous MIF signal transduction via pharmacological activation” to address “susceptibility to ischemic (heart) tissue damage.”
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