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How the world got lost on
the road to an anti-aging pill
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April 2, 2013: by ResveratrolNews
There is no question about it – Big Pharma and its minions of researchers are attempting to develop resveratrol analogs (look-alike molecules) that will garner billions in sales as a resveratrol-like drug. The objective of the game is to patent a molecule that is alleged to exceed the biological activity of a natural molecule like resveratrol.
Some of the specific objectives are to improve resveratrol’s antioxidant activity, improve its anti-inflammatory properties, elevate its anti-viral activity, produce higher blood serum concentrations and greater stability, and increase its cancer cell-killing effect, etc. Patents are being filed on improved resveratrol-like molecules.
But at the same time is Big Pharma attempting to disparage and subjugate resveratrol as a third-class molecule?
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March 26, 2013: by Bill Sardi
Reply to Bill Gifford’s demand (New Republic online) for a red wine pill to materialize that lives up to its calling as a molecular mimic of a calorie-restricted diet to reliably produce unprecedented prolongation of the human healthspan as well as achieve maximum lifespan.
Bill Gifford, writing online for the New Republic, asks “Where’s My Red Wine Pill?” in the wake of confusing headlines which recently said the quest for an anti-aging pill is back on track now that a Harvard scientist has re-confirmed resveratrol (rez-vair-a-trol) targets the Sirtuin-1 survival gene and that a 150-year lifespan may soon be common.
The confusion emanates from the many incongruent facts that surround this scientific re-discovery, the most prominent being the European drug company that purchased a developmental red wine pill company located near Boston is now shutting its U.S.-based operation down — an announcement that followed the gene-target breakthrough by just a few days.
Of course, connecting the dots may be difficult for some, but not for all, especially those longevity seekers who have been following this pharmacological shell game for some time now.
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March 25, 2013: by ResveratrolNews
Tune in to a radio Interview with Bill Sardi, talking about the prospect of a red wine longevity pill, with David Stouder on KEST-San Francisco radio.
Bill Sardi talks about his first encounter in 2003 with a Harvard professor who claimed to have discovered a red wine molecule that activates a key gene also activated by a limited-calorie diet which doubles the lifespan of laboratory animals. That’s where the story begins, but not where it ends. Listen here:
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March 4, 2013: by Bill Sardi
[Antagonizing effect of resveratrol on the lipid peroxidative damage induced by lead in mice].
Liu F, Xue Z, Zhang N, Wang W, Chen C, Li W.
Wei Sheng Yan Jiu. 2012 Nov;41(6):920-4. Chinese.
Natural polyphenols may ameliorate damage induced by copper overload.
Arnal N, Tacconi de Alaniz MJ, Marra CA.
Food Chem Toxicol. 2012 Feb;50(2):415-22. doi: 10.1016/j.fct.2011.10.037. Epub 2011 Oct 19.
PMID: 22036966 [PubMed – indexed for MEDLINE]
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February 11, 2013: by Bill Sardi
Biotechnologist Dr. Bruce Bryan emails to say his grandmother, who lived to 109 years of age, in good health most of the way, because he gave her 5 milligrams of deprenyl every morning.
Deprenyl (selegiline) is a drug that was developed in the 1960s for its anti-depressant effects (it is a monoamine oxidase MAO enzyme inhibitor) and is now primarily prescribed for Parkinson’s disease sufferers (trade names Eldepryl, Emsam, Zelapar, Azilect). It is surprising to learn that deprenyl (selegiline) is a molecule similar to methamphetamine, an illicit street drug, but is not psycho-active nor does it create addiction.
In the mid-1990s animal experiments revealed deprenyl prolongs life, first demonstrated in rodents and then dogs. It also was discovered that Deprenyl not only inhibited MAO but it worked in the brain by increasing the activity of internal (endogenous) antioxidant enzymes catalase and superoxide dismutase (SOD). However, deprenyl doesn’t activate glutathione like resveratrol does.
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January 25, 2013: by Bill Sardi
Well, lab mice are not humans, and they are fed in a controlled manner whereas humans can pony over to the kitchen and engorge themselves in snack foods, but resveratrol-fed animals exhibited far less arterial plaque (-52%) than animals given a statin drug (-40%). Furthermore, resveratrol equaled the reduction of circulating cholesterol as a statin drug (-19%). Since statin drugs do not prevent mortal heart attacks, but resveratrol pills do (at least in the animal lab), one wonders if it’s time to abandon Lipitor. — Bill Sardi, Resveratrolnews.com
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January 22, 2013: by Bill Sardi
The National Institutes of Health defines dyslexia as a developmental reading disorder or disability that occurs when the brain does not properly recognize and process certain symbols. Noted artist Elizabeth Berg has struggled with a more severe form of this disability for nearly six decades. As far back as Elizabeth can remember she was dyslexic.
Her earliest recall was when others pointed her disability out to her. Letters actually moved on the printed page. Letters like “b” were seen as a “d.” Her mother provided her with building blocks with raised letters on them to help her imprint the proper configuration of letters into her mind.
This disability didn’t hinder Lisa, as she is fondly called. She became a child prodigy and entered art college at a major university while still a young teenager.
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January 21, 2013: by Bill Sardi
Hartford, CT (Jan 20, 2013)- Noted red wine molecule heart researcher Dipak Das PhD has filed a $35 million defamation claim against the University of Connecticut (U CONN) Health Center for wrongful termination, violation of the university’s by-laws, and lack of due process as protected by the 14th Amendment to the United States Constitution.
Dr. Das made worldwide headlines in January of 2012 when U CONN authorities issued a press release and posted a website alleging 145 claims of scientific fraud that were backed by 60,000 pages of evidence. However, that website was quickly taken offline after many of its allegations were publicly rebutted. Soon thereafter, it came to light that the university’s review board had never read the entire report and has instead relied upon a 23-page summary in its decision to dismiss Dr. Das from his position as director of the Cardiovascular Research Center at the UCONN Health Center.
Dr. Das conducted landmark animal studies that demonstrated the red wine molecule resveratrol (rez-vair-ah-troll) can limit damage to the animal heart during a heart attack and turn a mortal heart attack into a non-mortal event.
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January 7, 2013: by Bill Sardi
Professor Ole Vang
Resveratrol 2012
The release of your (mis)information from the RESVERATROL 2012 conclave is almost laughable. I’m laughing in my tears. Sadly, so many suffer from inability of the “resveratrol community” to come to any conclusions. How many more wasted decades before the professors can come to any agreement?
While your press statements said “there is not yet scientific evidence to recommend a general intake of resveratrol for prevention of lifestyle diseases,” and “trials in humans are necessary … to be absolutely sure of positive effects in humans,” your plea for more studies is falling on deaf ears.
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January 3, 2013: by Bill Sardi
Report: RESVERATROL 2012 2nd International Conference of Resveratrol and Health (December 8, Leicester, England)
“Committee: a group of men who individually can do nothing, but as a group decide that nothing can be done.”
A collaborative group of scientific investigators, resveratrol raw-material manufacturers and branders of commercially available resveratrol-based products met in Leicester, England to chart the future direction for this miraculous natural molecule. The group covered a broad range of disorders that resveratrol addresses, which includes aging and cancer as well as important other issues such as optimal dosing and models for testing. Their full report can be read online here.
While the group concluded there is not unequivocal scientific data to support resveratrol for disease prevention in humans (OK for lab mice however) or human life extension (the only way to conclusively show resveratrol extends human life is to conduct a 99-year study), it did say there are encouraging preliminary results.
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