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How the world got lost on
the road to an anti-aging pill
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December 1, 2011: by Bill Sardi
In a six-month study conducted among metabolic syndrome patients (diabetes, high cholesterol, elevated blood sugar, obesity) in Japan who were taking multiple prescription drugs (statin cholesterol-lowering drugs and blood pressure-controlling drugs — diuretics, ACE inhibitors), a proprietary nutriceutical (Longevinex®) produced a major health benefit over and above that provided by prescription drugs — improved ability of arteries to widen (dilate) with increased heart rate and blood flow.
Drs. Haime Otani at Kansai Medical University in Moriguchi, Japan and lead researcher Dipak K Das at the University of Connecticut Medical School, say “currently available pharmacological drugs are frequently not sufficiently effective.” They go on to say: “A salient finding of the present study is that the improvement of endothelial function was observed in patients taking Longevinex® whose disease conditions were already being managed by standard therapy for lifestyle-related disease.” The endothelium is in inner lining of arterial walls that controls arterial diameter and blood flow.
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November 11, 2011: by Bill Sardi
Researchers are slow to concede that non-Darwinian models of aging may best explain human longevity.
In the Darwinian model an individual might have a genetic mutation inherited from their mother or father or both which is passed on to them. A gene mutation is defined as a substitution, deletion or insertion of an incorrect nucleotide on the DNA ladder. Adenine, guanine, cytosine and thymine represent the four nucleotide proteins that comprise the rungs on the DNA ladder. For example, a genetically similar group of short-statured people in Ecuador exhibit a gene mutation in a growth factor gene that confers unusual longevity upon them.
Contrary to static genes, epigenetics is the dynamic protein-making property of genes where genes produce (express) or negatively produce (silence) proteins. Alterations in genes that do not change the sequence of DNA nucleotides describe epigenetics.
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November 6, 2011: by Bill Sardi
For 8 years now, since a Harvard Professor announced a red wine molecule (resveratrol) prolong the life of yeast cells and later fruit flies, roundworms and finally over-fed laboratory mice, a relatively small number of people have been taking resveratrol pills. But subsequent studies showed laboratory mice fed a standard calorie diet did not live longer when their diet was supplemented with high-dose resveratrol (equivalent to 365 and 1565 mg human equivalent) and a pharmaceutical company ceased further research and development on its resveratrol-based drug. Then the gene target of resveratrol (sirtuin1) was brought into question and some news reports temporarily concluded resveratrol is no fountain of youth.
But suddenly a striking study in humans has brought resveratrol, well, back to life. Researchers in the Netherlands not only report for the first time that low-dose resveratrol mimics a calorie restricted diet in humans, but it significantly lowered blood pressure, favorably altered resting metabolic rate and activated over 450 genes, something no pharmaceutical drug has demonstrated to date. Furthermore, it was shown that the dose employed in the study, 150 milligrams, achieved the same blood concentration as much higher doses in laboratory animals. A growing body of research now points to low-dose resveratrol as being beneficial and mega-doses as being counterproductive.
One of the key aspects of resveratrol is that it is known as a hormetic agent. Hormesis is where a low-dose toxin triggers defenses in the body that produce profound health effects. This is the magic of resveratrol. At high doses resveratrol is no longer a hormetic agent.
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: by Bill Sardi
The science of human aging is accelerating at a rapid pace. The monthly calendar causes a number of scientific breakthroughs to be announced all at once as scientific journals are published around the 1st day of the month. Three stunning developments were announced this first week of November 2011. Summarily they were:
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November 1, 2011: by Bill Sardi
Las Vegas, NV (Nov 1, 2011) – For the first time the red wine molecule resveratrol has busted out of the confines of the animal laboratory and into the human arena where researchers report striking results.
The bottom line: for those individuals who exercise regularly and count calories, add a red wine pill to your daily regimen. For those sedentary Americans who overeat, a resveratrol (rez-vair-ah-troll) pill may actually supplant gym workouts and deprivation diets. That’s the latest news issued by European researchers in an online report published in the journal Cell Metabolism, as reported by ABC News.
The large cloud of scientific doubt over whether resveratrol actually targets a survival gene and serves as molecular mimic of a limited-calorie diet was lifted today as researchers report a modest dose of this red wine molecule mimics a calorie-restricted diet and/or endurance training in humans. Prior studies in laboratory mice were either inconclusive or disappointing.
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October 8, 2011: by Bill Sardi
The anti-diabetic drug Avandia (chemical name – rosiglitazone) is widely associated with increased risk for heart attacks and has been broadly criticized as potentially unsafe. However, the underlying mechanism behind potentially life-threatening events has remained obscure. Furthermore, some studies show this drug induces heart attacks while others do not.
Researchers in The Netherlands took smooth muscle cells (human source) from the lining of blood vessels, grew them in a lab dish, and found that the drug anti-diabetic drug rosiglitazone (Avandia-brand name) accelerates calcification in these cells, a mechanism that could help explain why Avandia is associated with adverse outcomes. 21816156
That Avandia use also leads to accelerated calcium loss from bone suggests another link to side effects caused by Avandia. It appears Avandia doesn’t initiate arterial calcifications but accelerates calcifications via decreased production of a key enzyme (alkaline phosphatase).
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October 2, 2011: by ResveratrolNews
So many times this author has lamented at how brainwashed Americans have become. Shown a picture of a 100-year old man blowing out the candles on his birthday cake, almost every person responds by saying “I never want to live that long.”
Strange isn’t it, the promise of super longevity, what Spanish explorer Juan Ponce de Leon long sought after, to conquer aging, the scourge of humanity, is no longer on the minds of most Americans.
An anti-aging pill didn’t top the list of desired inventions in an MIT survey conducted years ago – beat out by biodegradable plastic, a driverless car and an fully automated home, of all things.
While we may distance ourselves from any idea of lining up to die like people did in the movie Soylent Green, where people who had expired were processed into food in an overpopulated world where food shortages were rampant. But most Americans say they favor quality over quantity of life, as if these two never coexist.
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September 28, 2011: by Bill Sardi
All roads to adult wellness and longevity lead to resveratrol, but the public isn’t buying it. An estimated 345 producers of dietary supplements have all raced to enter their version of resveratrol pills into the marketplace, but not much more than 100,000 American take these red wine pills. It is inexplicable why resveratrol continues to astound in the research laboratory but physicians are loathe to recommend it and consumers reticent to take this pill that may be the pill that ends all other pills.
The broad biological scope of the red wine molecule resveratrol is becoming legendary. Dr. Dipak Das at the University of Connecticut has documented the large number of genes that resveratrol controls. Resveratrol is beneficial for brain, heart, liver, blood circulation, immunity, cholesterol, blood clotting, etc, etc. It is difficult to address the breadth of resveratrol’s biological action without writing an encyclopedia.
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September 26, 2011: by Bill Sardi
While online scientific reports published in the last 30 days, registered at Pubmed.gov– the National Library of Medicine’s access page to thousands of scientific journals, were saying the red wine molecule resveratrol (rez-vair-ah-troll) protects heart muscle cells prior to a heart attack, blocks lesions that occur in the back of the eyes in an animal model of diabetes, has the potential to ward off age-related brain disorders and has strong anti-tumor activity, a number of major news media outlets were airing headlines stories which said something to the contrary:
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September 22, 2011: by Bill Sardi
Nothing new here, we’ve discussed this a couple of times in prior reports, that the road to longevity is not dependent upon a single gene, nor solely upon the Sirtuin1 survival gene, and it doesn’t require 1000 bottles of red wine to produce the same positive biological effects seen in the animal lab. But red-wine resveratrol pills are back in the headlines again today for yet another round of scientific scrutiny
“It turns out, the researchers who brought us to the longevity party may have had the wrong gene target in mind and maybe the elixir for perpetual youth is more of a low-octane mixed drink closer to that found in red wine rather than plain resveratrol juice, but we need to recognize there was no scientific or public interest in longevity pills till 2001 when MIT and Harvard researchers first identified a key gene that is activated when living organisms are placed on a limit calorie diet,” says Bill Sardi, spokesperson for Longevinex®, a leading maker of resveratrol pills.
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