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How the world got lost on
the road to an anti-aging pill
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August 21, 2020: by Bill Sardi
Cancer cells are cunning. They evade the immune system via a protein called PD-L1 that hides cancer cells from tumor-attacking cells like neutrophils, macrophages that digest malignant cells, and natural killer cells that literally blow up cancerous cells. Inhibition of PD-L1 is essential for cancer immunotherapy to work.
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August 16, 2020: by Bill Sardi
Without a proven vaccine, vaccine-reliant human populations remain vulnerable to COVID-19 coronavirus lung infections. Maybe even vaccines won’t be able to conquer COVID-19. Vaccine makers haven’t been able to obtain licensure of a coronavirus vaccine in over a decade.
Operation Warp Speed to fast-track a COVID-19 vaccine may be met with disappointment say some experts. Humanity may be holding its breath for a vaccine that may never materialize. A spokesperson for The World Health Organization stated in July that “a coronavirus vaccine will not be available this year.” But there is political and financial pressure to take shortcuts, skip Phase 3 testing, show the vaccine produces antibodies equivalent to natural exposure, and start Phase 4 widespread immunization.
Oh, a COVID-19 vaccine may gain licensure, but will it be safe and effective when so many shortcuts are being taken?
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August 2, 2020: by Bill Sardi
Resveratrol is a natural compound found in grape seeds, peels and red wine. Resveratrol inhibits infections caused by multiple pathogens and shows inhibiting effects in a variety of human viruses, including influenza virus, herpes simplex virus, respiratory syncytial virus, HIV-1, varicella-zoster virus, enterovirus-71, human meta-pneumovirus, human rhinovirus-16, polyoma virus and cytomegalovirus.
Resveratrol has antiviral activity against respiratory viruses and certain anti-inflammatory effects, so it can be used as an adjuvant treatment for respiratory infections.
Resveratrol has a wide range of antiviral effects by down-regulating inflammatory signal transduction, which is mainly associated with the inhibition of viral replication, viral protein synthesis, gene expression, and nucleic acid synthesis.
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July 24, 2020: by Bill Sardi
The medical miracles associated with resveratrol continue to astound. To name some:
Late last year (2019) I wrote a report entitled RESVERATROL UNCHAINED: Is Resveratrol A Miracle Molecule? Six resveratrol miracles were mentioned: 1) cancer destroyer; 2) metabolic regulator; 3) Recovery of memory; 4) Heart attacks without damage; 5) Restoration of sight to the near blind; and 6) stem cells. An earlier report described how resveratrol mimics estrogen and performs real miracles.
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July 20, 2020: by Bill Sardi
A massive genetic evaluation encompassing data from over 1 million people concludes iron metabolism genes are involved in human aging and explains why individuals live longer than their peers. The database analysis was equivalent to studying 1.75 million lifespans and more than 60,000 extremely long-lived people.
This adds to the body of science behind the overmineralization theory of aging as postulated by this author. The progressive accumulation of iron, copper and calcium, beginning in males after full childhood growth and in females with the onset of menopause and cessation of menstrual blood (iron) losses, are drivers of aging.
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July 1, 2020: by Bill Sardi
For some-time now brain researchers have pretty well reached consensus that accumulation of iron in the brain accelerates brain aging. A “rusty brain” is a likely trigger for Alzheimer’s memory loss. For unexplained reasons, this accepted theory has not developed into any practiced treatment for brain disease.
There are prescription drugs for Alzheimer’s disease but they only mildly relieve symptoms, not causes of brain disease, and they have difficulty traversing the blood-brain barrier. Why the FDA allows ineffective drugs to remain on the market also goes unexplained. In fact, anti-psychotic drugs double the risk for death among Alzheimer’s patients. Family members of Alzheimer’s patients are completely deceived that the drugs prescribed for this dreaded disease are beneficial.
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June 19, 2020: by Bill Sardi
Of acute concern are “immunity passports” that are a proposed requirement for air travel. Those individuals who developed immunity without antibodies would not be granted passports.
Ben Lazarus, a features editor for the UK’s MAIL ON SUNDAY, tested positive for COVID-19 in March of 2020 but subsequently tested negative in three successive tests in the following month. Does this mean natural immunity is not lasting and even vaccination would wane and repeated immunizations will be required. No one knows for sure.
A just-released study of hospital workers who were exposed to infected patients reveals only 4% of 23,000 had antibodies, but researchers estimate 25% contracted the COVID-19 disease.
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June 15, 2020: by Bill Sardi
Many longevity seekers have heard all about the Sirtuin1 survival gene, that gene that is activated when humans are under physical or mental stress, such as during starvation or intentional calorie restriction. The seminal work on this was done by David Sinclair PhD, of Harvard Medical School, in 2003. An anti-aging pill was at hand.
As it so happened, the wine-drinking French had high cholesterol numbers but a far lower rate of death from coronary artery disease than North Americans, a healthy practice attributed to resveratrol and other similar molecules in aged French wine. In the 1990s this became known as the French Paradox. Given that resveratrol molecularly mimics a limited calorie diet, a link was made between wine and longevity.
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May 20, 2020: by Bill Sardi
MIT researchers made news headlines over a discovery that could help people not only live longer but retain their memory and other mental capacities throughout life.
There are three ways to control genes: 1) by activation or inactivation of proteins, called gene expression or silencing; 2) alteration of microRNA; or 3) by tightening or loosening DNA strands around spools called histone bodies. Histone bodies are comprised of lysine and arginine. Think of a DNA strand like a cord wrapped around a tennis ball (histone body). When strands of DNA are bound loosely around histone bodies, the DNA sequences can be “read” and activated. When DNA strands are tightened around histone bodies, the genes are shut off.
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May 9, 2020: by Bill Sardi
Resveratrol elevates NAD + (Nicotinamide adenine dinucleotide), a molecule that is considered to have anti-aging properties via its elevation of cell energy. IT has been said that “all roads to longevity lead to NAD+.” NAD+ that is naturally derived from niacin. Resveratrol elevated NAD+ by a more powerful mechanism than niacin (vitamin B3). Niacin precursors nicotinamide riboside (Niagen) and Nicotinamide Mononucleotide (NMN) are widely touted as dietary supplements as precursors of NAD+. Sixty years of science points to a derivative of niacin, nicotinamide, that stimulates NAD+. But the question remains: does plain niacin or niacinamide elevate NAD+ in a far more economical way? We now have a definitive answer to that question.
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