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How the world got lost on
the road to an anti-aging pill
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July 20, 2020: by Bill Sardi
A massive genetic evaluation encompassing data from over 1 million people concludes iron metabolism genes are involved in human aging and explains why individuals live longer than their peers. The database analysis was equivalent to studying 1.75 million lifespans and more than 60,000 extremely long-lived people.
This adds to the body of science behind the overmineralization theory of aging as postulated by this author. The progressive accumulation of iron, copper and calcium, beginning in males after full childhood growth and in females with the onset of menopause and cessation of menstrual blood (iron) losses, are drivers of aging.
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July 1, 2020: by Bill Sardi
For some-time now brain researchers have pretty well reached consensus that accumulation of iron in the brain accelerates brain aging. A “rusty brain” is a likely trigger for Alzheimer’s memory loss. For unexplained reasons, this accepted theory has not developed into any practiced treatment for brain disease.
There are prescription drugs for Alzheimer’s disease but they only mildly relieve symptoms, not causes of brain disease, and they have difficulty traversing the blood-brain barrier. Why the FDA allows ineffective drugs to remain on the market also goes unexplained. In fact, anti-psychotic drugs double the risk for death among Alzheimer’s patients. Family members of Alzheimer’s patients are completely deceived that the drugs prescribed for this dreaded disease are beneficial.
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June 19, 2020: by Bill Sardi
Of acute concern are “immunity passports” that are a proposed requirement for air travel. Those individuals who developed immunity without antibodies would not be granted passports.
Ben Lazarus, a features editor for the UK’s MAIL ON SUNDAY, tested positive for COVID-19 in March of 2020 but subsequently tested negative in three successive tests in the following month. Does this mean natural immunity is not lasting and even vaccination would wane and repeated immunizations will be required. No one knows for sure.
A just-released study of hospital workers who were exposed to infected patients reveals only 4% of 23,000 had antibodies, but researchers estimate 25% contracted the COVID-19 disease.
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June 15, 2020: by Bill Sardi
Many longevity seekers have heard all about the Sirtuin1 survival gene, that gene that is activated when humans are under physical or mental stress, such as during starvation or intentional calorie restriction. The seminal work on this was done by David Sinclair PhD, of Harvard Medical School, in 2003. An anti-aging pill was at hand.
As it so happened, the wine-drinking French had high cholesterol numbers but a far lower rate of death from coronary artery disease than North Americans, a healthy practice attributed to resveratrol and other similar molecules in aged French wine. In the 1990s this became known as the French Paradox. Given that resveratrol molecularly mimics a limited calorie diet, a link was made between wine and longevity.
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May 20, 2020: by Bill Sardi
MIT researchers made news headlines over a discovery that could help people not only live longer but retain their memory and other mental capacities throughout life.
There are three ways to control genes: 1) by activation or inactivation of proteins, called gene expression or silencing; 2) alteration of microRNA; or 3) by tightening or loosening DNA strands around spools called histone bodies. Histone bodies are comprised of lysine and arginine. Think of a DNA strand like a cord wrapped around a tennis ball (histone body). When strands of DNA are bound loosely around histone bodies, the DNA sequences can be “read” and activated. When DNA strands are tightened around histone bodies, the genes are shut off.
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May 9, 2020: by Bill Sardi
Resveratrol elevates NAD + (Nicotinamide adenine dinucleotide), a molecule that is considered to have anti-aging properties via its elevation of cell energy. IT has been said that “all roads to longevity lead to NAD+.” NAD+ that is naturally derived from niacin. Resveratrol elevated NAD+ by a more powerful mechanism than niacin (vitamin B3). Niacin precursors nicotinamide riboside (Niagen) and Nicotinamide Mononucleotide (NMN) are widely touted as dietary supplements as precursors of NAD+. Sixty years of science points to a derivative of niacin, nicotinamide, that stimulates NAD+. But the question remains: does plain niacin or niacinamide elevate NAD+ in a far more economical way? We now have a definitive answer to that question.
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March 22, 2020: by Bill Sardi
A newly published report indicates beta cyclodextrin, a solubilizing and anti-cholesterol agent in Longevinex®, inhibits attachment of coronaviruses to infect cells. According to a report published in the March 2020 issue of Acta Biomedica, cyclodextrin also inhibits the molecular doorway (ACE2) for coronaviruses to enter cells. Cyclodextrin essentially competes with viral targets for entry into healthy cells. Cyclodextrins are sugar-like molecules that serve as stabilizers and as a molecular delivery system.
Longevinex® Provides Five Molecules That Either Inhibit Coronavirus Infection Or Support Overall Immunity
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February 27, 2020: by Bill Sardi
A predicament of old age is that vitamin C blood levels which once were maintained in youth cannot be easily maintained in the senior years of life. Some of this inability to maintain healthy vitamin C levels emanates from the loss of recycling of vitamin C in red blood cells.
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February 23, 2020: by Bill Sardi
Take a gander at the chart below. Data shows when intake of all alcoholic beverages is combined (wine, beer, spirits), only wine at modest intake levels (3-5 drinks/week to 1-2 drinks a day) markedly lowers the risk for death compared to other alcoholic beverages (purple).
When broken down by type of alcoholic beverage, data shows only modest wine consumption results in a striking decline in mortality
(-27%) compared to beer (increased risk for death: +37%-153% and alcohol spirits (increased risk +9-73%). [Alcohol spirits are defined as 20+% beverage alcohol content: whiskey, vodka, rum, tequila, sake, brandy.]
At high intake of ANY alcoholic beverage including wine, mortality risk increased. But at modest intake levels only wine (-27% relative risk) reduced mortality rates compared to modest intake of beer (-2%) and alcohol spirits (-3%).
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February 17, 2020: by Bill Sardi
There are vast differences in biological aging in Americans due to dietary and environmental “epigenetic” factors that switch genes on or off. Of the estimated 25,000 genes in every cell in the human body, these genes vary widely in their protein-making (epigenetics).
Researchers now report <https://www.dailymail.co.uk/news/article-8010985/DNA-analysis-shows-60-year-old-person-genetic-age-100.html> they found a 66-year old had the biological age of 114 while a 59-year old was biologically 23. Differences in smoking rates, obesity and stress were identified as drivers of aging.
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