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August 30, 2012: by Bill Sardi
Members of the Calorie Restriction Society are likely throwing an ice cream party tonight knowing their limited calorie diet may not double their lifespan as it has in laboratory animals. But wait. Hold up on those banana splits till the science gets sorted out.
The quest to live longer is not embraced by many. Most desire quality over quantity of life. But for those who would like to achieve superlongevity via calorie restriction, a recent study has, at least temporarily, dashed their hopes.
The problem with the nonsense science you will be reading in the next few days is that biologists may be using the wrong markers of disease and aging and are too quick to give up on calorie restriction before sorting out its own science.
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August 18, 2012: by Bill Sardi
Joyce, 75 years old and struggling to maintain her eyesight, prepares for the worst. She had undergone 17 unsuccessful injections of medicine into her eyes without visual improvement. She had to pay hundreds of dollars for each injection while on a limited income. Her savings are now depleted. There is no place to turn. A friend advises her to try resveratrol pills. She says she will try them when she can get enough money to buy them. But if she doesn’t find help soon her vision may be permanently and irreversibly impaired.
Fortunately, an empathetic supplier of resveratrol (rez-vair-ah-troll) pills rush-ships her some samples. Within days her vision clears and within a few short weeks she is seeing well enough to pass her driver’s license vision test.
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August 16, 2012: by Bill Sardi
Scientists report today that heroin and morphine addiction can be blocked by inhibition of an immune cell receptor called toll-like receptor-4 (TLR-4). It has been reported that resveratrol specifically inhibits TLR-4. See reports below.
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August 8, 2012: by Bill Sardi
Given a background where efforts to extend lifespan in the laboratory using resveratrol have been mixed, with life extension being demonstrated in yeast cells, fruit flies, roundworms and high-fat fed mice but not normal-calorie fed mice, the life-prolonging effects of resveratrol were recently demonstrated among honey bees. The bees were fed a lower and 4X higher dose of resveratrol and lived 38% and 33% longer respectively. This effect was abolished when the bees were subjected to an environment of pure oxygen. The honey bees the ingested the highest does of resveratrol did not eat as much food under normal feeding conditions. The full-text report can be accessed here. – Copyright 2012 ResveratrolNews.com
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August 2, 2012: by Bill Sardi
Georgetown University researchers are widely publicizing their planned study of the red wine molecule resveratrol (rez-vair-ah-trol) among adults over 50 years of age with early signs of Alzheimer’s disease.
Alzheimer’s patients have already flocked to retail stores to purchase resveratrol pills, having heard of the planned study. And while it is indeed a very promising molecule for Alzheimer’s disease (one report called it a “boon for treating” the disease), there is justifiable concern that the study design, namely the dosage of resveratrol to be used in the study, may produce a negative result, produce unwanted side effects and more importantly, doom the future of resveratrol for years to come.
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July 15, 2012: by Bill Sardi
This report is being published in 20-point type for the visually impaired.
It’s one thing to bilk online consumers with false and misleading advertising, but it’s entirely another to launch online advertising intended to deceive the near-blind into buying a dietary supplement that could lead to permanent loss of vision.
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July 7, 2012: by Bill Sardi
In what is being billed as “a breakthrough in epigenetic science” (that is, a controllable gene mechanism), British scientists have discovered a unique genetic switch that produces a destructive enzyme involved in joint damage. The enzyme is identified as MMP13 and excessive activity of this enzyme leads to the wear-and-tear form of arthritis (osteoarthritis). The report says this discovery “offers a new epigenetic path toward a cure for osteoarthritis.” An abstract of the breakthrough report can be found here.
It is interesting to note here that not a word was mentioned about natural MMP13 enzyme inhibitors. Polyphenols, natural antioxidants found in grapes, berries, pomegranates, tea leaves, are natural enzyme inhibitors. One widely studied polyphenol is resveratrol, known as a red wine molecule. There are multiple studies showing resveratrol powerfully inhibits MMP13. You can link to read abstracts of these studies here, here, here and here. Why wait for modern pharmacology to develop a high-priced synthetic MMP13 inhibitor when you can purchase resveratrol directly, without prescription at vitamin shops? Copyright 2012 Bill Sardi Resveratrol News Not for posting at other websites.
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July 6, 2012: by Bill Sardi
Resveratrol might not kill off bacteria straight off, but it does inhibit the ability of germs to adhere to the tissue walls of the gut. This is the same way cranberry inhibits bacterial infection in the bladder. If bacteria can’t congregate and spread they will be killed off by roaming white blood cells. In an era of antibiotic resistance this information becomes more valuable. Certainly, those who consume red wine or resveratrol pills with meals reduce their risk of food poisoning.
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: by Bill Sardi
Researchers in Vienna report that red wine, via its succinic acid content, stimulate gastric acid and that red wine provokes more acid secretion than white wine. This beneficial effect is produced by the irritation of the stomach lining, much like bitters are used for the same purpose. An abstract of the report is presented below.
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June 23, 2012: by ResveratrolNews
J Nutr. 2012 Jun 20. [Epub ahead of print]
Khandelwal AR, Hebert VY, Kleinedler JJ, Rogers LK, Ullevig SL, Asmis R, Shi R, Dugas TR.
Department of Pharmacology, Toxicology and Neuroscience, and.
Restenosis is a critical complication of angioplasty and stenting. Restenosis is multifactorial, involving endothelial injury, inflammation, platelet activation, and vascular smooth muscle cell (VSMC) proliferation. Thus, dietary strategies to prevent restenosis likely require the use of more than one agent. Resveratrol (R) and quercetin (Q) are polyphenols that are known to exhibit vascular protective effects. We tested whether R and Q administered in the diet interact to inhibit vessel stenosis in mice with a carotid injury. B6.129 mice were administered a high-fat diet containing 21% fat and 0.2% cholesterol along with R (25 mg/kg), Q (10 mg/kg), or R + Q for 2 wk. A carotid injury was induced and the mice were again administered the enriched diet for 2 wk. Compared with the controls, R significantly decreased stenosis, assessed as an intima:media ratio, by 76%. Although Q treatment alone exhibited no effect, it potentiated the effect of R in that treatment with R + Q significantly decreased the intima:media ratio by 94%. Moreover, this effect was greater than that of R treatment alone (P < 0.05). Although treatments with R, Q, and R + Q significantly affected platelet activation and endothelial function, the responses observed for R + Q were less than additive. Specifically, the effects of R + Q were less than the sum of effects for treatments with R and Q alone. In contrast, treatment with R + Q exhibited more-than-additive effects on inflammatory markers and significant interactions between R and Q were observed. The presence of synergy between R and Q was thus tested in cultures of VSMC and macrophages. Isobolographic analysis revealed that 2:1 molar ratios of R:Q exhibited synergistic inhibition of VSMC proliferation and macrophage chemotaxis. In conclusion, in combination, R and Q can interact to reduce the extent of restenosis, perhaps due to their synergistic inhibition of VSMC proliferation and inflammation.
PMID: 22718033
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