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How the world got lost on
the road to an anti-aging pill
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October 11, 2012: by Bill Sardi
It might be a hard sell. How would anybody know such a pill would work till they lived decades spending hard-earned money for it? If one could guarantee that a person would live to a certain age by taking a pill every day, let’s say 102 years based upon some yet undetermined biological measure, would anybody really want to know the day of their demise?
Being involved in the marketing of such a pill, I have often jokingly offered the following tongue-in-cheek guarantee to those prospective consumers deliberating purchase of an anti-aging pill. “If you live to 100 years of age, send a copy of your birth certificate and record of your purchases of the pill, and we will ship you a free supply for the remainder of your life. If you take the pill religiously and you don’t live to the age of 100 years, send us the receipts of your purchases and you will receive a full refund.” Now, just how to collect?
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October 9, 2012: by ResveratrolNews
Editor’s Correspondence | Oct 8, 2012
Shlomit Gorelik, PhD; Joseph Kanner, PhD; Ron Kohen, PhD
Authors Affiliations: Institute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel (Drs Gorelik and Kohen); and Department of Food Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel (Dr Kanner).
Arch Intern Med. 2012;172(18):1424-1425. doi:10.1001/archinternmed.2012.3638.
We read with great interest the article by Pan et al1 discussing the results of 2 prospective cohort studies addressing the issue of red meat consumption and mortality. The authors found a positive correlation between red meat consumption and an increased risk in total cardiovascular disease (CVD) and cancer mortality. They also proposed the substitution of other healthy protein sources to lower mortality risks due to CVD and cancer.
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September 30, 2012: by Bill Sardi
Modern medicine becomes more and more disingenuous every day. Expensive cures preferred over more effective and less problematic natural remedies. An example of this is presented below. A report published at Science Daily shows that white blood cells called macrophages accumulate cholesterol in their attempt to remove excesses from the circulatory system. However, cholesterol over-bloated macrophages will become what are called foam cells that then trigger inflammation within arteries. So researchers claim they have altered an old problematic drug to facilitate exit (efflux) of cholesterol from macrophages. It’s heralded as a breakthrough. But they ignore the fact that resveratrol, a natural molecule, does the same thing. See the report below published in 2006 showing resveratrol limits cholesterol accumulation in human macrophages. By the way, the researchers are conceding their long-held idea of lowering cholesterol production in the liver has been a misdirection. — Copyright 2012 Resveratrolnews.com
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August 30, 2012: by Bill Sardi
Members of the Calorie Restriction Society are likely throwing an ice cream party tonight knowing their limited calorie diet may not double their lifespan as it has in laboratory animals. But wait. Hold up on those banana splits till the science gets sorted out.
The quest to live longer is not embraced by many. Most desire quality over quantity of life. But for those who would like to achieve superlongevity via calorie restriction, a recent study has, at least temporarily, dashed their hopes.
The problem with the nonsense science you will be reading in the next few days is that biologists may be using the wrong markers of disease and aging and are too quick to give up on calorie restriction before sorting out its own science.
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August 18, 2012: by Bill Sardi
Joyce, 75 years old and struggling to maintain her eyesight, prepares for the worst. She had undergone 17 unsuccessful injections of medicine into her eyes without visual improvement. She had to pay hundreds of dollars for each injection while on a limited income. Her savings are now depleted. There is no place to turn. A friend advises her to try resveratrol pills. She says she will try them when she can get enough money to buy them. But if she doesn’t find help soon her vision may be permanently and irreversibly impaired.
Fortunately, an empathetic supplier of resveratrol (rez-vair-ah-troll) pills rush-ships her some samples. Within days her vision clears and within a few short weeks she is seeing well enough to pass her driver’s license vision test.
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August 16, 2012: by Bill Sardi
Scientists report today that heroin and morphine addiction can be blocked by inhibition of an immune cell receptor called toll-like receptor-4 (TLR-4). It has been reported that resveratrol specifically inhibits TLR-4. See reports below.
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August 8, 2012: by Bill Sardi
Given a background where efforts to extend lifespan in the laboratory using resveratrol have been mixed, with life extension being demonstrated in yeast cells, fruit flies, roundworms and high-fat fed mice but not normal-calorie fed mice, the life-prolonging effects of resveratrol were recently demonstrated among honey bees. The bees were fed a lower and 4X higher dose of resveratrol and lived 38% and 33% longer respectively. This effect was abolished when the bees were subjected to an environment of pure oxygen. The honey bees the ingested the highest does of resveratrol did not eat as much food under normal feeding conditions. The full-text report can be accessed here. – Copyright 2012 ResveratrolNews.com
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August 2, 2012: by Bill Sardi
Georgetown University researchers are widely publicizing their planned study of the red wine molecule resveratrol (rez-vair-ah-trol) among adults over 50 years of age with early signs of Alzheimer’s disease.
Alzheimer’s patients have already flocked to retail stores to purchase resveratrol pills, having heard of the planned study. And while it is indeed a very promising molecule for Alzheimer’s disease (one report called it a “boon for treating” the disease), there is justifiable concern that the study design, namely the dosage of resveratrol to be used in the study, may produce a negative result, produce unwanted side effects and more importantly, doom the future of resveratrol for years to come.
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July 15, 2012: by Bill Sardi
This report is being published in 20-point type for the visually impaired.
It’s one thing to bilk online consumers with false and misleading advertising, but it’s entirely another to launch online advertising intended to deceive the near-blind into buying a dietary supplement that could lead to permanent loss of vision.
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July 7, 2012: by Bill Sardi
In what is being billed as “a breakthrough in epigenetic science” (that is, a controllable gene mechanism), British scientists have discovered a unique genetic switch that produces a destructive enzyme involved in joint damage. The enzyme is identified as MMP13 and excessive activity of this enzyme leads to the wear-and-tear form of arthritis (osteoarthritis). The report says this discovery “offers a new epigenetic path toward a cure for osteoarthritis.” An abstract of the breakthrough report can be found here.
It is interesting to note here that not a word was mentioned about natural MMP13 enzyme inhibitors. Polyphenols, natural antioxidants found in grapes, berries, pomegranates, tea leaves, are natural enzyme inhibitors. One widely studied polyphenol is resveratrol, known as a red wine molecule. There are multiple studies showing resveratrol powerfully inhibits MMP13. You can link to read abstracts of these studies here, here, here and here. Why wait for modern pharmacology to develop a high-priced synthetic MMP13 inhibitor when you can purchase resveratrol directly, without prescription at vitamin shops? Copyright 2012 Bill Sardi Resveratrol News Not for posting at other websites.
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