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How the world got lost on
the road to an anti-aging pill
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November 1, 2012: by Bill Sardi
Researchers in Italy analyzed 14 brands of resveratrol pills and found only 5 that met their labeled value for dosage. The brands were not identified.
The difference between the labeled and actual dose may be attributed to degradation of the molecule. The active form of this molecule (trans resveratrol), degrades to its less active form (cis resveratrol) upon exposure to light. Heat and oxygen (oxidation) can also degrade resveratrol. Light exposure actually “isomerizes” resveratrol into a different molecule — trans to cis.
Indeed, the researchers tested for cis resveratrol and found it was prevalent in many of the mislabeled brands, which suggests the product may have been exposed to environmental factors during extraction from a botanical source, during manufacturing, or possibly during shipping of shelf storage.
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October 26, 2012: by Bill Sardi
Comment: Yet another poorly designed study that one might think was intended to kibosh resveratrol. How does resveratrol improve normal? If it worked (lowered blood sugar) it would have created hypoglycemia. Resveratrol works synergistically in red wine in tandem with others molecules such as quercetin and ferulic acid. Hence, a so-called red wine pill should attempt to provide an array of small molecules. The hormesis effect where a low dose biological stressor triggers the body to produce internal antioxidants is not considered here. Consider this study with a grain of salt. Resveratrol has already been demonstrated to produce health benefits in humans. – Bill Sardi, ResveratrolNews.com
Cell Metabolism, 25 October 2012
Copyright 2012 Elsevier Inc. All rights reserved.
10.1016/j.cmet.2012.09.015
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October 19, 2012: by Bill Sardi
Since its initial discovery in 2000 by researchers in Japan, the hormone known as fibroblast growth factor-21 (FGF21) has intrigued biologists and endocrinologists. Mouse FGF21 is highly identical to human FGF21, making it useful for laboratory comparison.
It didn’t take long for investigators to realize FGF21 is a “novel therapeutic agent for human metabolism” in the regulation of sugar utilization, particularly in fat cells (adipocytes) in the liver. Therapeutic provision of FGF21 to laboratory mice reduces blood sugar levels and these animals are resistant to obesity. And FGF21 does not induce hypoglycemia (low blood sugar), cancer or weight gain at any tested dose in diabetic or healthy animals. Biologists were beginning to think of it as an ideal hormone/drug to treat diabetes.
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October 11, 2012: by Bill Sardi
It might be a hard sell. How would anybody know such a pill would work till they lived decades spending hard-earned money for it? If one could guarantee that a person would live to a certain age by taking a pill every day, let’s say 102 years based upon some yet undetermined biological measure, would anybody really want to know the day of their demise?
Being involved in the marketing of such a pill, I have often jokingly offered the following tongue-in-cheek guarantee to those prospective consumers deliberating purchase of an anti-aging pill. “If you live to 100 years of age, send a copy of your birth certificate and record of your purchases of the pill, and we will ship you a free supply for the remainder of your life. If you take the pill religiously and you don’t live to the age of 100 years, send us the receipts of your purchases and you will receive a full refund.” Now, just how to collect?
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October 9, 2012: by ResveratrolNews
Editor’s Correspondence | Oct 8, 2012
Shlomit Gorelik, PhD; Joseph Kanner, PhD; Ron Kohen, PhD
Authors Affiliations: Institute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel (Drs Gorelik and Kohen); and Department of Food Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel (Dr Kanner).
Arch Intern Med. 2012;172(18):1424-1425. doi:10.1001/archinternmed.2012.3638.
We read with great interest the article by Pan et al1 discussing the results of 2 prospective cohort studies addressing the issue of red meat consumption and mortality. The authors found a positive correlation between red meat consumption and an increased risk in total cardiovascular disease (CVD) and cancer mortality. They also proposed the substitution of other healthy protein sources to lower mortality risks due to CVD and cancer.
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September 30, 2012: by Bill Sardi
Modern medicine becomes more and more disingenuous every day. Expensive cures preferred over more effective and less problematic natural remedies. An example of this is presented below. A report published at Science Daily shows that white blood cells called macrophages accumulate cholesterol in their attempt to remove excesses from the circulatory system. However, cholesterol over-bloated macrophages will become what are called foam cells that then trigger inflammation within arteries. So researchers claim they have altered an old problematic drug to facilitate exit (efflux) of cholesterol from macrophages. It’s heralded as a breakthrough. But they ignore the fact that resveratrol, a natural molecule, does the same thing. See the report below published in 2006 showing resveratrol limits cholesterol accumulation in human macrophages. By the way, the researchers are conceding their long-held idea of lowering cholesterol production in the liver has been a misdirection. — Copyright 2012 Resveratrolnews.com
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August 30, 2012: by Bill Sardi
Members of the Calorie Restriction Society are likely throwing an ice cream party tonight knowing their limited calorie diet may not double their lifespan as it has in laboratory animals. But wait. Hold up on those banana splits till the science gets sorted out.
The quest to live longer is not embraced by many. Most desire quality over quantity of life. But for those who would like to achieve superlongevity via calorie restriction, a recent study has, at least temporarily, dashed their hopes.
The problem with the nonsense science you will be reading in the next few days is that biologists may be using the wrong markers of disease and aging and are too quick to give up on calorie restriction before sorting out its own science.
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August 18, 2012: by Bill Sardi
Joyce, 75 years old and struggling to maintain her eyesight, prepares for the worst. She had undergone 17 unsuccessful injections of medicine into her eyes without visual improvement. She had to pay hundreds of dollars for each injection while on a limited income. Her savings are now depleted. There is no place to turn. A friend advises her to try resveratrol pills. She says she will try them when she can get enough money to buy them. But if she doesn’t find help soon her vision may be permanently and irreversibly impaired.
Fortunately, an empathetic supplier of resveratrol (rez-vair-ah-troll) pills rush-ships her some samples. Within days her vision clears and within a few short weeks she is seeing well enough to pass her driver’s license vision test.
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August 16, 2012: by Bill Sardi
Scientists report today that heroin and morphine addiction can be blocked by inhibition of an immune cell receptor called toll-like receptor-4 (TLR-4). It has been reported that resveratrol specifically inhibits TLR-4. See reports below.
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August 8, 2012: by Bill Sardi
Given a background where efforts to extend lifespan in the laboratory using resveratrol have been mixed, with life extension being demonstrated in yeast cells, fruit flies, roundworms and high-fat fed mice but not normal-calorie fed mice, the life-prolonging effects of resveratrol were recently demonstrated among honey bees. The bees were fed a lower and 4X higher dose of resveratrol and lived 38% and 33% longer respectively. This effect was abolished when the bees were subjected to an environment of pure oxygen. The honey bees the ingested the highest does of resveratrol did not eat as much food under normal feeding conditions. The full-text report can be accessed here. – Copyright 2012 ResveratrolNews.com
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