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How the world got lost on
the road to an anti-aging pill
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July 6, 2012: by Bill Sardi
Resveratrol might not kill off bacteria straight off, but it does inhibit the ability of germs to adhere to the tissue walls of the gut. This is the same way cranberry inhibits bacterial infection in the bladder. If bacteria can’t congregate and spread they will be killed off by roaming white blood cells. In an era of antibiotic resistance this information becomes more valuable. Certainly, those who consume red wine or resveratrol pills with meals reduce their risk of food poisoning.
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: by Bill Sardi
Researchers in Vienna report that red wine, via its succinic acid content, stimulate gastric acid and that red wine provokes more acid secretion than white wine. This beneficial effect is produced by the irritation of the stomach lining, much like bitters are used for the same purpose. An abstract of the report is presented below.
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June 23, 2012: by ResveratrolNews
J Nutr. 2012 Jun 20. [Epub ahead of print]
Khandelwal AR, Hebert VY, Kleinedler JJ, Rogers LK, Ullevig SL, Asmis R, Shi R, Dugas TR.
Department of Pharmacology, Toxicology and Neuroscience, and.
Restenosis is a critical complication of angioplasty and stenting. Restenosis is multifactorial, involving endothelial injury, inflammation, platelet activation, and vascular smooth muscle cell (VSMC) proliferation. Thus, dietary strategies to prevent restenosis likely require the use of more than one agent. Resveratrol (R) and quercetin (Q) are polyphenols that are known to exhibit vascular protective effects. We tested whether R and Q administered in the diet interact to inhibit vessel stenosis in mice with a carotid injury. B6.129 mice were administered a high-fat diet containing 21% fat and 0.2% cholesterol along with R (25 mg/kg), Q (10 mg/kg), or R + Q for 2 wk. A carotid injury was induced and the mice were again administered the enriched diet for 2 wk. Compared with the controls, R significantly decreased stenosis, assessed as an intima:media ratio, by 76%. Although Q treatment alone exhibited no effect, it potentiated the effect of R in that treatment with R + Q significantly decreased the intima:media ratio by 94%. Moreover, this effect was greater than that of R treatment alone (P < 0.05). Although treatments with R, Q, and R + Q significantly affected platelet activation and endothelial function, the responses observed for R + Q were less than additive. Specifically, the effects of R + Q were less than the sum of effects for treatments with R and Q alone. In contrast, treatment with R + Q exhibited more-than-additive effects on inflammatory markers and significant interactions between R and Q were observed. The presence of synergy between R and Q was thus tested in cultures of VSMC and macrophages. Isobolographic analysis revealed that 2:1 molar ratios of R:Q exhibited synergistic inhibition of VSMC proliferation and macrophage chemotaxis. In conclusion, in combination, R and Q can interact to reduce the extent of restenosis, perhaps due to their synergistic inhibition of VSMC proliferation and inflammation.
PMID: 22718033
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June 19, 2012: by ResveratrolNews
June 19th, 2012 in Health
A natural compound found in some fruits, nuts and red wine may enhance exercise training and performance, demonstrates newly published medical research from the University of Alberta.
Principal investigator Jason Dyck and his team found out in experiments that high doses of the natural compound resveratrol improved physical performance, heart function and muscle strength in lab models.
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June 12, 2012: by Bill Sardi
We hear of potential problems associated with exposure to herbicides and pesticides, artificial sweeteners, drugs in tap water, heavy metals, plasticizers, petroleum products, bisphenol A hormone disruptor in the lining of tin cans, as well as chlorine, fluoride, and hundreds of other chemicals. Maybe some human exposure to trivial doses of potential toxins is harmless and is rapidly negated or excreted by detoxification systems within the human body, but what about all of them representing a total modern chemical/environmental threat? A study of these aggregate toxins may be beyond what modern toxicology can examine.
Researchers Melissa L Sokolosky and Michael J Wargovich at the Hollings Cancer Center, Medical University of South Carolina, explore reasons why there are certain less developed geographical regions in the world that exhibit a 26-fold lower incidence for colon/rectal cancer compared to areas where more advanced human civilizations live. This fact suggests something having to do with modern living is involved in the promotion of cancer.
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June 10, 2012: by Bill Sardi
Say it again: nicotinamide riboside (nik-oh-tin-amide ry-bo-side).
In the wake of the many advances and setbacks involved in marketing resveratrol pills, another small vitamin-like molecule enters the anti-aging pill market, that is, if it can be produced economically and be shown to work in humans at a much lower dose than in the animal lab.
The “new molecule” is a cousin of niacin. Said to be an incredibly small molecule that is difficult to find in foods (it is found in the whey of milk and beer), its molecular weight is 255.247 Daltons, slightly larger than the red wine molecule resveratrol. It works on some of the same gene targets as resveratrol, such as SIrtuin1 and Sirtuin 3, and subsequently FOXO1, Pgc1a and SOD, genes known to produce anti-aging effects.
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May 29, 2012: by Bill Sardi
Yes, what is obvious has been confirmed. Despite unfounded claims that all of the research studies showing resveratrol protects heart muscle tissue during a heart attack, even Wikipedia spreads misinformation that that fact is in question due to bogus allegations of scientific fraud against a leading resveratrol scientist. Canadian researchers unequivocally show that resveratrol protects the heart under conditions of biological stress induced by instillation of hydrogen peroxide by maintaining antioxidant enzymes (catalase, superoxide dismutase). Once damaged (scarred), heart muscle cells (cardiomyocytes) are not rapidly repaired. So it is critical to protect these cells. Resveratrol does something that no existing cardiac drug an do — protect the heart prior to a heart attack (this is called cardioprotection). It has been called the most ideal form of heart protection. Based upon animal lab studies, cardioprotection has been demonstrated to have the potential to turn otherwise mortal heart attacks into non-mortal events, which is more than aspirin or statin drugs can do. — Bill Sardi, ResveratrolNews.com
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May 16, 2012: by Bill Sardi
The fact is, such a pill already exists.
Click on the underlined links above to learn more.
–Bill Sardi, ResveratrolNews.com
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May 9, 2012: by ResveratrolNews
From: The Association for Research in Vision & Ophthalmology (ARVO) annual meeting, Fort Lauderdale, Fla.,
Ft. Lauderdale, FL (May 6, 2012) – There may be new found hope for patients whose vision is threatened when medicine injected directly into the eyes fails to cause abnormal blood vessels to recede. While injectable drugs called angiogenesis (an-gee-oh-jen-esis) inhibitors are considered a modern miracle and have become the standard of care for patients with the fast-progressive form of macular degeneration, they are not foolproof. For the first time researchers report that an oral nutriceutical, used on a last-resort clinical basis, rapidly restores vision to otherwise hopeless patients who face permanent loss.
Stuart Richer OD, PhD, Director, Ocular Preventative Medicine-Eye Clinic, James A. Lovell Federal Health Care Center, North Chicago, Illinois, says all other therapies were exhausted before employing the oral nutriceutical under compassionate-use protocols on a case-by-case basis. Usually most patients respond to medicine injected directly into the eyes, he says, but only about one in three patients recover driving vision and one in six patients go on to experience permanent vision loss and others may refuse needle injections directly into the eyes, making them candidates for this rescue medicine.
Three successfully treated cases were presented at the annual Association for Research in Vision & Ophthalmology meeting in Ft. Lauderdale, Florida.
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May 2, 2012: by Bill Sardi
http://www.nrcresearchpress.com/doi/pdf/10.1139/y2012-065
Dr. Thomas Netticadan
Canadian Centre for Agri-food Research
in Health and Medicine,
Winnipeg, Manitoba
Thank you for your comments published at Canadian Journal Physiology & Pharmacology regarding resveratrol research. ( http://www.nrcresearchpress.com/doi/pdf/10.1139/y2012-065 )
Let it be said that:
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