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How the world got lost on
the road to an anti-aging pill
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April 21, 2012: by ResveratrolNews
Abridged summary: researchers have found that even very low dose intermittent exposure (twice in a 5-day period) to hydrogen peroxide, which is generated by exposure to unfiltered sunlight, induces aging of cells in the outer layer of the skin (epidermis) but that the red wine molecule resveratrol completely blocks senescence of these cells which may be chronically exposed to solar ultraviolet radiation.
Researchers in the experiment presented below show that hydrogen peroxide (H2O2-)induced premature senescence in primary human keratinocytes (cells found in the outer layer of the skin/epidermis) can be prevented by AMPK activation. (AMPK is a master metabolic activating enzyme.)
Cells that are senescent are no longer capable of dividing and skin renewal. Thus, researchers found that: (1) a low dose of hydrogen peroxide (H2O2 50 µM) activates two primary genes (p53 and secondarily p21)in these cells and subsequently increased SA-Galactosidase (SA-Ga1) activity, a marker of cellular senescence, and that (2) prior activation of AMPK by resveratrol prevented these H2O2-induced changes
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April 17, 2012: by Bill Sardi
According to a recent survey, 1 in 10 drugs were prescribed for off-label (unproven) uses, most which were not substantiated by existing science. (Archives Internal Medicine April 16, 2012). Physicians frequently respond to patient inquiries about dietary supplements by saying they are “unproven.” However, that doesn’t seem to bother physicians if it is a drug.
Furthermore, there is no drug that cures cancer (chemotherapy drugs only need to temporarily shrink a tumor by 50% before drug/tumor resistance sets in to gain FDA approval).
There is no single drug (diuretics, beta blockers, ACE inhibitors, calcium blockers) that adequately controls high blood pressure, and then none address the most common cause of hypertension (inability of blood vessels to dilate upon mental or physical exertion).
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April 12, 2012: by Bill Sardi
Noted herbal researcher Bahrat Aggarwal PhD, of the University of Texas MD Anderson Cancer Center in Houston is the second major herbal researcher to be accused of scientific fraud this year. Word that 65 of his published papers were under scientific review began to be leaked first on the internet before news reports confirmed an investigation is underway.
Like Dipak Das, PhD, the University of Connecticut researcher who was charged with over a hundred counts of scientific deceit in January of this year, both researchers stand accused of altering graphic images in their published papers. And in both instances, there is unequivocal evidence of altered images in these published papers. However, interpretation of whether these altered images represent honest mistakes or intentional trickery is a bit more difficult.
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April 3, 2012: by Bill Sardi
The scourge of making a cheap sugar from corn is the prevalent plague of diabesity that has changed American waist lines and forced many into life-long insulin injections. An antidote to high fructose corn syrup (HFCS) would be ideal if Americans can’t back away from their desire for sweets. Sugars do create cravings for more sweet stuff as sugar-craving yeast overgrow in the digestive tract. About 50% of sugar intake in western society is derived from HFCS sugar in soft drinks. Certainly Americans have become hooked on this cheap sugar and are paying the price not only with poor health but rising health care costs. And to think HFCS was developed by none other than the US Department of Agriculture. So researchers in Eastern Europe put resveratrol, known as a red wine molecule, to the test to see if it would counter the adverse effects of HFCS. Whereas HFCS causes triglycerides and very-low density lipoproteins (cholesterol) to rise as well as blood pressure and insulin levels in laboratory rats, resveratrol supplementation “efficiently restored HFCS-induced deteriorations” said researchers. Here is the comparative data:
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April 2, 2012: by Bill Sardi
After 33 months, grey mouse lemurs who were given a 30%-lower calorie diet experienced an 81% reduction in insulin resistance (inability of cells to utilize insulin) while another group of animals given mega-dose resveratrol (200 milligrams per kilogram of body weight, or 14,000 mg human equivalent dose) experienced a 53% reduction in insulin resistance. Neither calorie restriction nor resveratrol produced any significant beneficial effects at 21 months suggesting beneficial effects for humans may take time to be realized. The study was published in a recent issue of the PLos One journal.
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: by Bill Sardi
All balding males pay attention. Put two-and-two together here. Resveratrol is potentially a remedy for baldness. Researchers have found that balding scalp areas exhibit high levels of an inflammatory agent called prostaglandin D2 (PDG2). See the first reference posted below. PGD2 inhibitors would serve to preserve hair growth. Why wait for expensive medicines? Resveratrol strong suppresses PGD2 at low concentration, as evidenced in the second reference provided below. Maybe resveratrol pills should be sold with a comb. — Copyright 2012 Bill Sardi, ResveratrolNews.com
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April 1, 2012: by Bill Sardi
In the past decade or so red-wine resveratrol has been the most intensively studied anti-aging molecule. Resveratrol’s calling is that of a molecular mimic of a calorie-restricted diet that has been found to double the lifespan of all life forms tested.
Despite all the research, the confirmation of the first anti-aging pill has been elusive if for no other reason than the impracticality of conducting a long-term study to validate such an idea. The only conclusive evidence would be a long-term (many decades long) study. Many thousands of people would have to be followed for 8-10 decades to produce convincing data.
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March 29, 2012: by Bill Sardi
Yep, despite all of the evidence that resveratrol produces far greater and safer biological action at relatively low doses, biologists administered the human equivalent of 8000 milligrams of resveratrol to laboratory mice and found this “miracle molecule” to be ineffective at prolonging the life of these animals.
Why is this so? Are these researchers intentionally attempting to throw resveratrol under the bus? This question gets asked because all of these researchers are certainly aware of the hormesis effect, that a low-dose biological stressor activates key defenses in the body whereas a high-dose toxin is potentially lethal. Some of these researchers have even written about hormesis and resveratrol.
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March 23, 2012: by Bill Sardi
Worldwide headlines herald a test that may make it possible for cardiologists to predict an impending heart attack. The test may be particularly beneficial for people who have silent (non-painful) heart attacks or heart attacks that cannot be detected by conventional methods.
Compared to healthy adults, four times as many loose cells that slough off the inner lining of arteries, called endothelial cells, were found among heart attack patients who arrived at a hospital emergency room complaining of chest pain. A quicker and more efficient test is now being developed to count circulating endothelial cells in a blood sample.
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March 22, 2012: by Bill Sardi
With billions of dollars being spent on cancer research there is yet be declared any clearly proven measure to prevent cancer. Nor is there any proven cure once cancer is diagnosed. So the news headline that resveratrol (a red wine molecule) and genistein (a molecule found in soybeans) may be unique and promising anti-cancer agents is striking given all the money that is spent to develop synthetic anti-cancer drugs.
The problem is — I am not talking about the most recent scientific report about these molecules which says resveratrol and genistein are cancer-killing molecules that do not harm the DNA in healthy cells and are far less problematic than existing chemotherapy drugs, but about a similar report issued over a decade ago!
Nearly a decade ago pioneer researcher John M Pezzuto said, in regard to resveratrol, that “preclinical toxicity studies are underway that should be followed by human clinical trials. Imagine, resveratrol blocks cancer at all three stages of development – initiation, growth and spread (metastasis) – something no anti-cancer drug can do, yet there are few if any human clinical trials.
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